Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>

Clinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC d...

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Autores principales: Espinel-Ingroff, A., Chakrabarti, A., Chowdhary, A., Córdoba, Susana Beatriz, Dannaoui, E., Dufresne. P., Fothergill, A., Ghannoum, M., Gonzalez, G. M., Guarro, J., Kidd, S., Lass-Flörl, C., Meis, J. F., Pelaez, T., Tortorano, A. M., Turnidge, J.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146772
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-146772
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
spellingShingle Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
Espinel-Ingroff, A.
Chakrabarti, A.
Chowdhary, A.
Córdoba, Susana Beatriz
Dannaoui, E.
Dufresne. P.
Fothergill, A.
Ghannoum, M.
Gonzalez, G. M.
Guarro, J.
Kidd, S.
Lass-Flörl, C.
Meis, J. F.
Pelaez, T.
Tortorano, A. M.
Turnidge, J.
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
topic_facet Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
description Clinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 <i>Apophysomyces variabilis</i>, 32 <i>Cunninghamella bertholletiae</i>, 136 <i>Lichtheimia corymbifera</i>, 10 <i>Mucor indicus</i>, 123 <i>M. circinelloides</i>, 19 <i>M. ramosissimus</i>, 349 <i>Rhizopus arrhizus</i>, 146 <i>R. microsporus</i>, 33 <i>Rhizomucor pusillus</i>, and 36 <i>Syncephalastrum racemosum</i> isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for <i>L. corymbifera</i> were 1 and 2 μg/ml, those for <i>M. circinelloides</i> were 1 and 2 μg/ml, those for <i>R. arrhizus</i> were 2 and 4 μg/ml, and those for <i>R. microsporus</i> were 2 and 2 μg/ml, respectively; posaconazole ECVs for <i>L. corymbifera</i> were 1 and 2, those for <i>M. circinelloides</i> were 4 and 4, those for <i>R. arrhizus</i> were 1 and 2, and those for <i>R. microsporus</i> were 1 and 2, respectively; both itraconazole ECVs for <i>R. arrhizus</i> were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.
format Articulo
Articulo
author Espinel-Ingroff, A.
Chakrabarti, A.
Chowdhary, A.
Córdoba, Susana Beatriz
Dannaoui, E.
Dufresne. P.
Fothergill, A.
Ghannoum, M.
Gonzalez, G. M.
Guarro, J.
Kidd, S.
Lass-Flörl, C.
Meis, J. F.
Pelaez, T.
Tortorano, A. M.
Turnidge, J.
author_facet Espinel-Ingroff, A.
Chakrabarti, A.
Chowdhary, A.
Córdoba, Susana Beatriz
Dannaoui, E.
Dufresne. P.
Fothergill, A.
Ghannoum, M.
Gonzalez, G. M.
Guarro, J.
Kidd, S.
Lass-Flörl, C.
Meis, J. F.
Pelaez, T.
Tortorano, A. M.
Turnidge, J.
author_sort Espinel-Ingroff, A.
title Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_short Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_full Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_fullStr Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_full_unstemmed Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_sort multicenter evaluation of mic distributions for epidemiologic cutoff value definition to detect amphotericin b, posaconazole, and itraconazole resistance among the most clinically relevant species of <i>mucorales</i>
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/146772
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