Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice

Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detectio...

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Detalles Bibliográficos
Autores principales: Zanuzzi, Carolina Natalia, Scrochi, Mariela Rita, Fuentealba, Nadia Analía, Nishida, Fabián, Portiansky, Enrique Leo, Muglia, Cecilia Isabel, Gimeno, Eduardo Juan, Barbeito, Claudio Gustavo, Galosi, Cecilia Mónica
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Veterinaria
Safety Index
Average Weight Gain
RK13 Cell
Equid Herpesvirus
Muench Method
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146511
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.

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