Role of type IV collagen in prolactin release from anterior pituitaries of male rats

We previously demonstrated that laminin, a component of basement membranes, modulates pituitary hormone secretion. In the present study, we evaluated the effect of type IV collagen, another component of this membrane, on the release of prolactin (PRL) by anterior pituitary gland from adult male rats...

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Autores principales: Diaz, Emilce S., Rettori, Valeria, Suescun, María Olga, Lustig, Livia, McCann, Samuel M., Denduchis, Berta
Formato: Articulo
Lenguaje:Inglés
Publicado: 2002
Materias:
Ciencias Médicas
Biología
type IV collagen
prolactin
anterior pituitary
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146458
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-146458
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Biología
type IV collagen
prolactin
anterior pituitary
spellingShingle Ciencias Médicas
Biología
type IV collagen
prolactin
anterior pituitary
Diaz, Emilce S.
Rettori, Valeria
Suescun, María Olga
Lustig, Livia
McCann, Samuel M.
Denduchis, Berta
Role of type IV collagen in prolactin release from anterior pituitaries of male rats
topic_facet Ciencias Médicas
Biología
type IV collagen
prolactin
anterior pituitary
description We previously demonstrated that laminin, a component of basement membranes, modulates pituitary hormone secretion. In the present study, we evaluated the effect of type IV collagen, another component of this membrane, on the release of prolactin (PRL) by anterior pituitary gland from adult male rats. Hemipituitaries were incubated for 3 h with type IV collagen or antibodies against it and PRL release was studied. Rabbit IgG to type IV collagen at concentrations of 10⁻⁷ - 10⁻⁵ M had a significant stimulatory effect on PRL release, in comparison to normal rabbit serum IgG or medium alone used as controls. Type IV collagen induced a significant inhibitory effect on basal release of PRL at a concentration of 30 µg/mL. A slight decrease in PRL release was detected in thyrotropin-releasing hormone-stimulated hemipituitaries incubated with type IV collagen at all concentrations used. These results suggest that type IV collagen, similar to laminin-1, modulates PRL released from hemipituitaries, in vitro.
format Articulo
Articulo
author Diaz, Emilce S.
Rettori, Valeria
Suescun, María Olga
Lustig, Livia
McCann, Samuel M.
Denduchis, Berta
author_facet Diaz, Emilce S.
Rettori, Valeria
Suescun, María Olga
Lustig, Livia
McCann, Samuel M.
Denduchis, Berta
author_sort Diaz, Emilce S.
title Role of type IV collagen in prolactin release from anterior pituitaries of male rats
title_short Role of type IV collagen in prolactin release from anterior pituitaries of male rats
title_full Role of type IV collagen in prolactin release from anterior pituitaries of male rats
title_fullStr Role of type IV collagen in prolactin release from anterior pituitaries of male rats
title_full_unstemmed Role of type IV collagen in prolactin release from anterior pituitaries of male rats
title_sort role of type iv collagen in prolactin release from anterior pituitaries of male rats
publishDate 2002
url http://sedici.unlp.edu.ar/handle/10915/146458
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