Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation

The development of gastrointestinal tonometry was an important step in the monitoring of tissue dysoxia. It rapidly became a useful tool in basic research. In addition, and for the first time, a regional parameter could be used to detect and to treat hypoperfusion. From an experimental point of view...

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Detalles Bibliográficos
Autores principales:	Dubin, Arnaldo, Edul, Vanina Siham Kanoore, Ince, Can
Formato:	Libro Capitulo de libro
Lenguaje:	Español
Publicado:	Springer 2009
Materias:	Ciencias Médicas Microcirculatory perfusion Venous and Tissue PCO2
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/146227
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-146227
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Español
topic	Ciencias Médicas Microcirculatory perfusion Venous and Tissue PCO2
spellingShingle	Ciencias Médicas Microcirculatory perfusion Venous and Tissue PCO2 Dubin, Arnaldo Edul, Vanina Siham Kanoore Ince, Can Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation
topic_facet	Ciencias Médicas Microcirculatory perfusion Venous and Tissue PCO2
description	The development of gastrointestinal tonometry was an important step in the monitoring of tissue dysoxia. It rapidly became a useful tool in basic research. In addition, and for the first time, a regional parameter could be used to detect and to treat hypoperfusion. From an experimental point of view, tonometry adequately tracks intramucosal acidosis, i.e., the increase in intramucosal-arterial PCO2 difference (ΔPCO2). Likewise, the increase in ΔPCO2 is better than other systemic and intestinal variables to show tissue hypoperfusion in normal volunteers and in experimental models. Intramucosal acidosis is a sensitive predictor of gastric and colonic mucosal ischemia. Furthermore, gastric tonometry is an insightful predictor of outcome. This usefulness has been shown in postoperative, critically ill, septic and shock patients. Gastric tonometry might also be used to assess the effect of vasoactive drugs. Finally, intramucosal pH (pHi) has been evaluated as a guide for resuscitation. Gutierrez et al. demonstrated in a randomized controlled trial that pHi-guided therapy could decrease mortality in critically ill patients.
format	Libro Capitulo de libro
author	Dubin, Arnaldo Edul, Vanina Siham Kanoore Ince, Can
author_facet	Dubin, Arnaldo Edul, Vanina Siham Kanoore Ince, Can
author_sort	Dubin, Arnaldo
title	Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation
title_short	Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation
title_full	Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation
title_fullStr	Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation
title_full_unstemmed	Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation
title_sort	determinants of tissue pco₂ in shock and sepsis: relationship to the microcirculation
publisher	Springer
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/146227
work_keys_str_mv	AT dubinarnaldo determinantsoftissuepco2inshockandsepsisrelationshiptothemicrocirculation AT edulvaninasihamkanoore determinantsoftissuepco2inshockandsepsisrelationshiptothemicrocirculation AT incecan determinantsoftissuepco2inshockandsepsisrelationshiptothemicrocirculation
bdutipo_str	Repositorios
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Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation

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