Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice

The present study describes the changes in the endocrine pancreas of severely diabetic calmodulin-transgenic mice using light microscopic immunocyto-chemical and morphometric techniques. A marked reduction in the number and volume of islets, together with distortion of their normal architecture, was...

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Autores principales: Gómez Dumm, César Leandro Alberto, Gagliardino, Juan José, Atwater, Illani, Epstein, P. N.
Formato: Articulo
Lenguaje:Inglés
Publicado: 1994
Materias:
Ciencias Médicas
Pancreatic islet cells
Quantitative immunocytochemistry
Transgenic mice
Experimental diabetes
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146099
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-146099
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Pancreatic islet cells
Quantitative immunocytochemistry
Transgenic mice
Experimental diabetes
spellingShingle Ciencias Médicas
Pancreatic islet cells
Quantitative immunocytochemistry
Transgenic mice
Experimental diabetes
Gómez Dumm, César Leandro Alberto
Gagliardino, Juan José
Atwater, Illani
Epstein, P. N.
Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
topic_facet Ciencias Médicas
Pancreatic islet cells
Quantitative immunocytochemistry
Transgenic mice
Experimental diabetes
description The present study describes the changes in the endocrine pancreas of severely diabetic calmodulin-transgenic mice using light microscopic immunocyto-chemical and morphometric techniques. A marked reduction in the number and volume of islets, together with distortion of their normal architecture, was found in diabetic mice. In addition, the volume density of both endocrine tissue and B-cells was decreased. An irregular distribution of non-B-cells was also observed in diabetic animals. The volume density and the percentage of A-cells appeared increased. However, when quantified per area unit, the number of all the islet cell types diminished, although only the decrease in B-cell number was statistically significant. The decrease in B-cell mass might account for the diabetic state developed in this animal model.
format Articulo
Articulo
author Gómez Dumm, César Leandro Alberto
Gagliardino, Juan José
Atwater, Illani
Epstein, P. N.
author_facet Gómez Dumm, César Leandro Alberto
Gagliardino, Juan José
Atwater, Illani
Epstein, P. N.
author_sort Gómez Dumm, César Leandro Alberto
title Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
title_short Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
title_full Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
title_fullStr Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
title_full_unstemmed Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
title_sort quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
publishDate 1994
url http://sedici.unlp.edu.ar/handle/10915/146099
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AT gagliardinojuanjose quantitativeimmunocytochemicalstudyofisletcellpopulationsindiabeticcalmodulintransgenicmice
AT atwaterillani quantitativeimmunocytochemicalstudyofisletcellpopulationsindiabeticcalmodulintransgenicmice
AT epsteinpn quantitativeimmunocytochemicalstudyofisletcellpopulationsindiabeticcalmodulintransgenicmice
bdutipo_str Repositorios
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