The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice

The relationship between protein malnutrition and ethanol consumption as modulating factors of the genetic response to xenobiotics was studied. BALB/c mice of both sexes were fed for three weeks after weaning either with a normal diet containing 25% protein or a hypoproteic diet containing 5% protei...

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Detalles Bibliográficos
Autores principales: Terreros, M. C., De Luca, Julio César, Dulout, Fernando Noel
Formato: Articulo
Lenguaje:Inglés
Publicado: 1993
Materias:
Biología
Protein malnutrition
Ethanol consumption
Chromosomal damage
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/145490
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-145490
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Protein malnutrition
Ethanol consumption
Chromosomal damage
spellingShingle Biología
Protein malnutrition
Ethanol consumption
Chromosomal damage
Terreros, M. C.
De Luca, Julio César
Dulout, Fernando Noel
The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice
topic_facet Biología
Protein malnutrition
Ethanol consumption
Chromosomal damage
description The relationship between protein malnutrition and ethanol consumption as modulating factors of the genetic response to xenobiotics was studied. BALB/c mice of both sexes were fed for three weeks after weaning either with a normal diet containing 25% protein or a hypoproteic diet containing 5% protein. Half of the animals received 20% ethanol in drinking water. Cytogenetic analysis was performed in bone marrow cells. Slides were stained for C-banding in order to assure the accurate scoring of dicentric chromosomes. Results obtained showed an increased frequency of dicentric chromosomes in mice fed with the hypoproteic diet (5.45 dicentrics per 100 cells) in contrast to mice fed with the normal diet (0.61 dicentrics per 100 cells). Ethanol consumption increased the frequency of chromosomal damage, but no differences in the effect of ethanol between mice fed with the normal diet and mice fed with the hypoproteic diet (16.33 and 16.80 dicentrics per 100 cells respectively). The enhanced frequency of dicentric chromosomes in animals fed with the hypoproteic diet might have been originated from the increase or the improper repair of chromosome breaks. The similarity in the response to ethanol consumption in animals fed either with the normal or the hypoproteic diet might have been provoked by a decrease of alcohol dehydrogenase (ADH) level in undernourished mice. The chromosomal damage due to ethanol may be lower in undernourished mice than in mice fed with the normal diet due to the reduced amount of circulating acetaldehyde able to induce chromosomal damage. The results obtained are an evidence of the role played by the diet in the modulation of the genetic response to xenobiotics.
format Articulo
Articulo
author Terreros, M. C.
De Luca, Julio César
Dulout, Fernando Noel
author_facet Terreros, M. C.
De Luca, Julio César
Dulout, Fernando Noel
author_sort Terreros, M. C.
title The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice
title_short The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice
title_full The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice
title_fullStr The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice
title_full_unstemmed The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice
title_sort effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice
publishDate 1993
url http://sedici.unlp.edu.ar/handle/10915/145490
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