Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney

The cellular origin of trisomy 7 in non-neoplastic kidney tissue specimens from 10 patients, seven with malignant tumors and three with non-neoplastic kidney diseases, was studied by the MAC (morphology antibody chromosomes) technique, which allows analysis of cellular morphology/histology, immunoph...

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Detalles Bibliográficos
Autores principales: Knuutila, Sakari, Larramendy, Marcelo Luis, Elfving, Peter, El-Rifai, Wael, Miettinen, Aaro, Mitelman, Felix
Formato: Articulo
Lenguaje:Inglés
Publicado: 1995
Materias:
Biología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/145352
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-145352
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
spellingShingle Biología
Knuutila, Sakari
Larramendy, Marcelo Luis
Elfving, Peter
El-Rifai, Wael
Miettinen, Aaro
Mitelman, Felix
Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney
topic_facet Biología
description The cellular origin of trisomy 7 in non-neoplastic kidney tissue specimens from 10 patients, seven with malignant tumors and three with non-neoplastic kidney diseases, was studied by the MAC (morphology antibody chromosomes) technique, which allows analysis of cellular morphology/histology, immunophenotype, and chromosomal aneuploidy by conventional cytogenetics, and/or fluorescent in situ hybridization in both interphase and mitotic cells. In primary cultures, trisomy 7 was detected primarily in cytokeratin-positive cells. Among freshly isolated renal cells, the trisomy was mainly observed in proximal tubular cells positive to brush-border antigen, and, to a lesser extent, in distal tubular cells positive to Tamm-Horsfall glycoprotein. The frequency of trisomy 7 in lymphocytes expressing CD3 or CD22 antigens isolated from non-neoplastic and tumor tissues was substantially lower than in the epithelial cells and was not increased compared with that in control lymphocytes from peripheral blood. The results thus demonstrate that the non-neoplastic kidney cells with trisomy 7 are mainly normal epithelial cells, preferentially those of the proximal tubule.
format Articulo
Articulo
author Knuutila, Sakari
Larramendy, Marcelo Luis
Elfving, Peter
El-Rifai, Wael
Miettinen, Aaro
Mitelman, Felix
author_facet Knuutila, Sakari
Larramendy, Marcelo Luis
Elfving, Peter
El-Rifai, Wael
Miettinen, Aaro
Mitelman, Felix
author_sort Knuutila, Sakari
title Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney
title_short Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney
title_full Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney
title_fullStr Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney
title_full_unstemmed Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney
title_sort trisomy 7 in non-neoplastic tubular epithelial cells of the kidney
publishDate 1995
url http://sedici.unlp.edu.ar/handle/10915/145352
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