Bis(oxalato)dioxovanadate(V) and bis(oxalato)oxoperoxo-vanadate(V) complexes: spectroscopic characterization and biological activity

Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2]·3H2O and K3[VO(O2)(C2O4)2]·1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The m...

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Detalles Bibliográficos
Autores principales: León, Ignacio Esteban, Etcheverry, Susana Beatriz, Parajón Costa, Beatriz Susana, Baran, Enrique José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Química
Vanadium(V)
Bis(oxalato) complexes
Peroxo ligand
Vibrational spectra
Electronic spectra
Osteosarcoma cells in culture
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/145349
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2]·3H2O and K3[VO(O2)(C2O4)2]·1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The monoperoxo complex shows a very strong antiproliferative activity (at 100-μM concentration, this complex diminished the cell viability ca. 80 %), whereas the dioxo complex was inactive.

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