Ultrastructural responses of pancreatic β cells to metabolic alkalosis

The ultrastructural changes in pancreatic β cells were studied following glucose-induced insulin secretion in vitro, at two different extracellular pH (7.4 and 7.8). The pancreata perfused at pH 7.4 exhibited a biphasic insulin response to glucose challenge together with signs of increased emiocytot...

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Detalles Bibliográficos
Autores principales:	Gómez Dumm, César Leandro Alberto, Rebolledo, Oscar Remigio, Gagliardino, Juan José
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	1979
Materias:	Biología Ciencias Médicas Insulin secretion Electron microscopy Acid-base changes Pancreas perfusion
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/145237
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-145237
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Biología Ciencias Médicas Insulin secretion Electron microscopy Acid-base changes Pancreas perfusion
spellingShingle	Biología Ciencias Médicas Insulin secretion Electron microscopy Acid-base changes Pancreas perfusion Gómez Dumm, César Leandro Alberto Rebolledo, Oscar Remigio Gagliardino, Juan José Ultrastructural responses of pancreatic β cells to metabolic alkalosis
topic_facet	Biología Ciencias Médicas Insulin secretion Electron microscopy Acid-base changes Pancreas perfusion
description	The ultrastructural changes in pancreatic β cells were studied following glucose-induced insulin secretion in vitro, at two different extracellular pH (7.4 and 7.8). The pancreata perfused at pH 7.4 exhibited a biphasic insulin response to glucose challenge together with signs of increased emiocytotic activity and numerous microtubules in the β cells. Conversely, the pancreata perfused at pH 7.8 showed a significant decrease in insulin secretion, and their β cells revealed scarce emiocytotic images and a marked increase of intracellular granulolysis. These results represent the ultrastructural correlate of the reduced insulin secretion produced by metabolic alkalosis in the perfused rat pancreas.
format	Articulo Articulo
author	Gómez Dumm, César Leandro Alberto Rebolledo, Oscar Remigio Gagliardino, Juan José
author_facet	Gómez Dumm, César Leandro Alberto Rebolledo, Oscar Remigio Gagliardino, Juan José
author_sort	Gómez Dumm, César Leandro Alberto
title	Ultrastructural responses of pancreatic β cells to metabolic alkalosis
title_short	Ultrastructural responses of pancreatic β cells to metabolic alkalosis
title_full	Ultrastructural responses of pancreatic β cells to metabolic alkalosis
title_fullStr	Ultrastructural responses of pancreatic β cells to metabolic alkalosis
title_full_unstemmed	Ultrastructural responses of pancreatic β cells to metabolic alkalosis
title_sort	ultrastructural responses of pancreatic β cells to metabolic alkalosis
publishDate	1979
url	http://sedici.unlp.edu.ar/handle/10915/145237
work_keys_str_mv	AT gomezdummcesarleandroalberto ultrastructuralresponsesofpancreaticbcellstometabolicalkalosis AT rebolledooscarremigio ultrastructuralresponsesofpancreaticbcellstometabolicalkalosis AT gagliardinojuanjose ultrastructuralresponsesofpancreaticbcellstometabolicalkalosis
bdutipo_str	Repositorios
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Ultrastructural responses of pancreatic β cells to metabolic alkalosis

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