The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration

The pharmacokinetics of a slow-release theophylline formulation was investigated following intravenous and oral administration at 10 mg/kg in horses. A tricompartmental model was selected to describe the intravenous plasma profile. The elimination half-life (t1/2β) was 16.91 ± 0.93 h, the apparent v...

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Detalles Bibliográficos
Autores principales: Errecalde, Jorge Oscar, Landoni, María Fabiana
Formato: Articulo
Lenguaje:Inglés
Publicado: 1992
Materias:
Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/143206
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-143206
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
spellingShingle Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
Errecalde, Jorge Oscar
Landoni, María Fabiana
The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
topic_facet Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
description The pharmacokinetics of a slow-release theophylline formulation was investigated following intravenous and oral administration at 10 mg/kg in horses. A tricompartmental model was selected to describe the intravenous plasma profile. The elimination half-life (t1/2β) was 16.91 ± 0.93 h, the apparent volume of distribution (Vd) was 1.35 ± 0.18 L/kg and the body clearance (ClB) was 0.061 ± 0.009 L kg−1 h. After oral administration the half-life of absorption was 1.24 ± 0.30 h, and the calculated bioavailability was above 100%. Thet1/2β after oral administration was 18.51 ± 1.75 h, only a little longer than that after intravenous administration. The slow release formulation did not exhibit any advantage in prolonging thet1/2β of theophylline in the horse.
format Articulo
Articulo
author Errecalde, Jorge Oscar
Landoni, María Fabiana
author_facet Errecalde, Jorge Oscar
Landoni, María Fabiana
author_sort Errecalde, Jorge Oscar
title The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_short The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_full The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_fullStr The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_full_unstemmed The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_sort pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
publishDate 1992
url http://sedici.unlp.edu.ar/handle/10915/143206
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AT errecaldejorgeoscar pharmacokineticsofaslowreleasetheophyllinepreparationinhorsesafterintravenousandoraladministration
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