Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis

It has been established that ZFP36 (also known as Tristetraprolin or TTP) promotes mRNA degradation of proteins involved in inflammation, proliferation and tumor invasiveness. In mammary epithelial cells ZFP36 expression is induced by STAT5 activation during lactogenesis, while in breast cancer ZFP3...

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Detalles Bibliográficos
Autores principales: Canzoneri, Romina, Naipauer, Julian, Stedile, Micaela Nadia, Rodriguez Peña, Agustina, Lacunza, Ezequiel, Gandini, Norberto Ariel, Curino, Alejandro Carlos, Facchinetti, Maria Marta, Coso, Omar A., Kordon, Edith C., Abba, Martín Carlos
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Biología
Ciencias Médicas
ZFP36
TTP
AP-1
Breast cancer
Mammary gland
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/143203
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-143203
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Médicas
ZFP36
TTP
AP-1
Breast cancer
Mammary gland
spellingShingle Biología
Ciencias Médicas
ZFP36
TTP
AP-1
Breast cancer
Mammary gland
Canzoneri, Romina
Naipauer, Julian
Stedile, Micaela Nadia
Rodriguez Peña, Agustina
Lacunza, Ezequiel
Gandini, Norberto Ariel
Curino, Alejandro Carlos
Facchinetti, Maria Marta
Coso, Omar A.
Kordon, Edith C.
Abba, Martín Carlos
Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
topic_facet Biología
Ciencias Médicas
ZFP36
TTP
AP-1
Breast cancer
Mammary gland
description It has been established that ZFP36 (also known as Tristetraprolin or TTP) promotes mRNA degradation of proteins involved in inflammation, proliferation and tumor invasiveness. In mammary epithelial cells ZFP36 expression is induced by STAT5 activation during lactogenesis, while in breast cancer ZFP36 expression is associated with lower grade and better prognosis. Here, we show that the AP-1 transcription factor components, i.e. JUN, JUNB, FOS, FOSB, in addition to DUSP1, EGR1, NR4A1, IER2 and BTG2, behave as a conserved co-regulated group of genes whose expression is associated to ZFP36 in cancer cells. In fact, a significant down-modulation of this gene network is observed in breast, liver, lung, kidney, and thyroid carcinomas compared to their normal counterparts. In breast cancer, the normal-like and Luminal A, show the highest expression of the ZFP36 gene network among the other intrinsic subtypes and patients with low expression of these genes display poor prognosis. It is also proposed that AP-1 regulates ZFP36 expression through responsive elements detected in the promoter region of this gene. Culture assays show that AP-1 activity induces ZFP36 expression in mammary cells in response to prolactin (PRL) treatment thorough ERK1/2 activation. These results suggest that JUN, JUNB, FOS and FOSB are not only co-expressed, but would also play a relevant role in regulating ZFP36 expression in mammary epithelial cells.
format Articulo
Articulo
author Canzoneri, Romina
Naipauer, Julian
Stedile, Micaela Nadia
Rodriguez Peña, Agustina
Lacunza, Ezequiel
Gandini, Norberto Ariel
Curino, Alejandro Carlos
Facchinetti, Maria Marta
Coso, Omar A.
Kordon, Edith C.
Abba, Martín Carlos
author_facet Canzoneri, Romina
Naipauer, Julian
Stedile, Micaela Nadia
Rodriguez Peña, Agustina
Lacunza, Ezequiel
Gandini, Norberto Ariel
Curino, Alejandro Carlos
Facchinetti, Maria Marta
Coso, Omar A.
Kordon, Edith C.
Abba, Martín Carlos
author_sort Canzoneri, Romina
title Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
title_short Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
title_full Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
title_fullStr Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
title_full_unstemmed Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
title_sort identification of an ap1-zfp36 regulatory network associated with breast cancer prognosis
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/143203
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