Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose

Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination of healthcare workers in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Rossi, Andrés Hugo, Ojeda, Diego Sebastian, Varese, Augusto, Sanchez, Lautaro, Gonzalez Lopez Ledesma, Maria M., Mazzitelli, Ignacio, Alvarez Juliá, Anabel, Oviedo Rouco, Santiago, Pallarés, Horacio M., Costa Navarro, Guadalupe S., Rasetto, Natali B., García, Corina I., Wenker, Shirley D., Ramis, Lila Y., Bialer, Magalí G., Leone, María José de, Hernando, C. Esteban, Sosa, Santiago, Bianchimano, Luciana, Rios, Antonella S., Treffinger Cienfuegos, Maria Soledad, Caramelo, Julio J., Longueira, Yesica, Laufer, Natalia, Alvarez, Diego E., Carradori, Jorge, Pedrozza, Dariana, Rima, Alejandra, Echegoyen, Cecilia, Ercole, Regina, Gelpi, Paula, Marchetti, Susana, Zubieta, Martín, Docena, Guillermo Horacio, Kreplak, Nicolás, Yanovsky, Marcelo J., Geffner, Jorge, Pifano, Marina, Gamarnik, Andrea V.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/143078
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-143078
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
spellingShingle Ciencias Médicas
Rossi, Andrés Hugo
Ojeda, Diego Sebastian
Varese, Augusto
Sanchez, Lautaro
Gonzalez Lopez Ledesma, Maria M.
Mazzitelli, Ignacio
Alvarez Juliá, Anabel
Oviedo Rouco, Santiago
Pallarés, Horacio M.
Costa Navarro, Guadalupe S.
Rasetto, Natali B.
García, Corina I.
Wenker, Shirley D.
Ramis, Lila Y.
Bialer, Magalí G.
Leone, María José de
Hernando, C. Esteban
Sosa, Santiago
Bianchimano, Luciana
Rios, Antonella S.
Treffinger Cienfuegos, Maria Soledad
Caramelo, Julio J.
Longueira, Yesica
Laufer, Natalia
Alvarez, Diego E.
Carradori, Jorge
Pedrozza, Dariana
Rima, Alejandra
Echegoyen, Cecilia
Ercole, Regina
Gelpi, Paula
Marchetti, Susana
Zubieta, Martín
Docena, Guillermo Horacio
Kreplak, Nicolás
Yanovsky, Marcelo J.
Geffner, Jorge
Pifano, Marina
Gamarnik, Andrea V.
Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose
topic_facet Ciencias Médicas
description Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination of healthcare workers in Argentina, measuring IgG anti-spike titers and neutralizing capacity after one and two doses in a cohort of naive or previously infected volunteers. By 21 days after receiving the first dose of vaccine, 94% of naive participants develop spike-specific IgG antibodies. A single Sputnik V dose elicits higher antibody levels and virus neutralizing capacity in previously infected individuals than in naive ones receiving the full two-dose schedule. The high seroconversion rate after a single dose in naive participants suggests a benefit of delaying second dose administration to increase the number of people vaccinated. The data presented provide information for guiding public health decisions in light of the current global health emergency.
format Articulo
Articulo
author Rossi, Andrés Hugo
Ojeda, Diego Sebastian
Varese, Augusto
Sanchez, Lautaro
Gonzalez Lopez Ledesma, Maria M.
Mazzitelli, Ignacio
Alvarez Juliá, Anabel
Oviedo Rouco, Santiago
Pallarés, Horacio M.
Costa Navarro, Guadalupe S.
Rasetto, Natali B.
García, Corina I.
Wenker, Shirley D.
Ramis, Lila Y.
Bialer, Magalí G.
Leone, María José de
Hernando, C. Esteban
Sosa, Santiago
Bianchimano, Luciana
Rios, Antonella S.
Treffinger Cienfuegos, Maria Soledad
Caramelo, Julio J.
Longueira, Yesica
Laufer, Natalia
Alvarez, Diego E.
Carradori, Jorge
Pedrozza, Dariana
Rima, Alejandra
Echegoyen, Cecilia
Ercole, Regina
Gelpi, Paula
Marchetti, Susana
Zubieta, Martín
Docena, Guillermo Horacio
Kreplak, Nicolás
Yanovsky, Marcelo J.
Geffner, Jorge
Pifano, Marina
Gamarnik, Andrea V.
author_facet Rossi, Andrés Hugo
Ojeda, Diego Sebastian
Varese, Augusto
Sanchez, Lautaro
Gonzalez Lopez Ledesma, Maria M.
Mazzitelli, Ignacio
Alvarez Juliá, Anabel
Oviedo Rouco, Santiago
Pallarés, Horacio M.
Costa Navarro, Guadalupe S.
Rasetto, Natali B.
García, Corina I.
Wenker, Shirley D.
Ramis, Lila Y.
Bialer, Magalí G.
Leone, María José de
Hernando, C. Esteban
Sosa, Santiago
Bianchimano, Luciana
Rios, Antonella S.
Treffinger Cienfuegos, Maria Soledad
Caramelo, Julio J.
Longueira, Yesica
Laufer, Natalia
Alvarez, Diego E.
Carradori, Jorge
Pedrozza, Dariana
Rima, Alejandra
Echegoyen, Cecilia
Ercole, Regina
Gelpi, Paula
Marchetti, Susana
Zubieta, Martín
Docena, Guillermo Horacio
Kreplak, Nicolás
Yanovsky, Marcelo J.
Geffner, Jorge
Pifano, Marina
Gamarnik, Andrea V.
author_sort Rossi, Andrés Hugo
title Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose
title_short Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose
title_full Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose
title_fullStr Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose
title_full_unstemmed Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose
title_sort sputnik v vaccine elicits seroconversion and neutralizing capacity to sars cov-2 after a single dose
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/143078
work_keys_str_mv AT rossiandreshugo sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT ojedadiegosebastian sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT vareseaugusto sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT sanchezlautaro sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT gonzalezlopezledesmamariam sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT mazzitelliignacio sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT alvarezjuliaanabel sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT oviedoroucosantiago sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT pallareshoraciom sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT costanavarroguadalupes sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT rasettonatalib sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT garciacorinai sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT wenkershirleyd sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT ramislilay sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT bialermagalig sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT leonemariajosede sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT hernandocesteban sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT sosasantiago sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT bianchimanoluciana sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT riosantonellas sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT treffingercienfuegosmariasoledad sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT caramelojulioj sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT longueirayesica sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT laufernatalia sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT alvarezdiegoe sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT carradorijorge sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT pedrozzadariana sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT rimaalejandra sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT echegoyencecilia sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT ercoleregina sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT gelpipaula sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT marchettisusana sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT zubietamartin sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT docenaguillermohoracio sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT kreplaknicolas sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT yanovskymarceloj sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT geffnerjorge sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT pifanomarina sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
AT gamarnikandreav sputnikvvaccineelicitsseroconversionandneutralizingcapacitytosarscov2afterasingledose
bdutipo_str Repositorios
_version_ 1764820459431395329

Ejemplares similares