Effectiveness of the first component of Gam-COVID-Vac (Sputnik V) on reduction of SARS-CoV-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in Argentina

Background A first-dose of various vaccines provides acceptable protection against infections by SARS-CoV-2 and evolution to the most severe forms of COVID-19. The recombinant adenovirus (rAd)-based vaccine, Gam-COVID-Vac (Sputnik V), was proven efficacious but information about effectiveness in the...

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Detalles Bibliográficos
Autores principales: González, Soledad E., Olszevicki, Santiago, Salazar, Martín R., Calabria, Ana, Regairaz, Lorena, Marín, Lupe, Campos, Patricia, Varela, Teresa, González Martínez, Veronica V., Ceriani, Leticia, Garcia, Enio, Kreplak, Nicolás, Pifano, Marina, Estenssoro, Elisa, Marsico, Franco
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
Vaccination
Covid-19
Immunization
Infectious diseases
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/142736
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-142736
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Vaccination
Covid-19
Immunization
Infectious diseases
spellingShingle Ciencias Médicas
Vaccination
Covid-19
Immunization
Infectious diseases
González, Soledad E.
Olszevicki, Santiago
Salazar, Martín R.
Calabria, Ana
Regairaz, Lorena
Marín, Lupe
Campos, Patricia
Varela, Teresa
González Martínez, Veronica V.
Ceriani, Leticia
Garcia, Enio
Kreplak, Nicolás
Pifano, Marina
Estenssoro, Elisa
Marsico, Franco
Effectiveness of the first component of Gam-COVID-Vac (Sputnik V) on reduction of SARS-CoV-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in Argentina
topic_facet Ciencias Médicas
Vaccination
Covid-19
Immunization
Infectious diseases
description Background A first-dose of various vaccines provides acceptable protection against infections by SARS-CoV-2 and evolution to the most severe forms of COVID-19. The recombinant adenovirus (rAd)-based vaccine, Gam-COVID-Vac (Sputnik V), was proven efficacious but information about effectiveness in the real-world setting is lacking. The aim of our study was to investigate the association between the rollout of the first component (rAd26) of Gam-COVID-Vac and PCR-positive tests, hospitalisations and deaths. Methods We conducted a retrospective cohort study which analyzed individuals aged 60-79 who self-registered in the online vaccination system of the Province of Buenos Aires, Argentina, from December 29, 2020 to March 21, 2021. Exclusion criteria were having a previous positive RT-PCR or antigen tests for SARS-CoV-2, having received other vaccines, or two doses of any vaccine. Proportions of new laboratory-confirmed SARS-CoV-2 infections, hospitalisations and deaths until 83 days of vaccination were compared between vaccinated and unvaccinated subjects. Vaccine effectiveness for the three outcomes was calculated as (1–OR) × 100. Kaplan-Meier cumulative incidence curves were constructed. Findings During the study period 415995 registered subjects received the first component of Gam-COVID-Vac; 40387 belonged to the 60-79 age group, and were compared to 38978 unvaccinated. Vaccine effectiveness for preventing laboratory-confirmed infections was 78•6% [CI95% 74·8 - 81·7]; and for reducing hospitalizations and deaths was, respectively, 87·6% [CI95% 80·3 - 92·2] and 84·8% [CI95% 75·0 - 90·7]. Effectiveness was high across all subgroups. Interpretation Similarly to other vaccines, the administration of one dose of Gam-COVID-Vac was effective for a wide range of COVID-19–related outcomes.
format Articulo
Articulo
author González, Soledad E.
Olszevicki, Santiago
Salazar, Martín R.
Calabria, Ana
Regairaz, Lorena
Marín, Lupe
Campos, Patricia
Varela, Teresa
González Martínez, Veronica V.
Ceriani, Leticia
Garcia, Enio
Kreplak, Nicolás
Pifano, Marina
Estenssoro, Elisa
Marsico, Franco
author_facet González, Soledad E.
Olszevicki, Santiago
Salazar, Martín R.
Calabria, Ana
Regairaz, Lorena
Marín, Lupe
Campos, Patricia
Varela, Teresa
González Martínez, Veronica V.
Ceriani, Leticia
Garcia, Enio
Kreplak, Nicolás
Pifano, Marina
Estenssoro, Elisa
Marsico, Franco
author_sort González, Soledad E.
title Effectiveness of the first component of Gam-COVID-Vac (Sputnik V) on reduction of SARS-CoV-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in Argentina
title_short Effectiveness of the first component of Gam-COVID-Vac (Sputnik V) on reduction of SARS-CoV-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in Argentina
title_full Effectiveness of the first component of Gam-COVID-Vac (Sputnik V) on reduction of SARS-CoV-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in Argentina
title_fullStr Effectiveness of the first component of Gam-COVID-Vac (Sputnik V) on reduction of SARS-CoV-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in Argentina
title_full_unstemmed Effectiveness of the first component of Gam-COVID-Vac (Sputnik V) on reduction of SARS-CoV-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in Argentina
title_sort effectiveness of the first component of gam-covid-vac (sputnik v) on reduction of sars-cov-2 confirmed infections, hospitalisations and mortality in patients aged 60-79: a retrospective cohort study in argentina
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/142736
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