The trophoblast clock controls transport across placenta in mice

In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, th...

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Detalles Bibliográficos
Autores principales:	Demarez, Cécile, Monteiro de Assis, Leonardo Vinícius, Krohn, Markus, Ramella, Nahuel Alberto, Schwaninger, Markus, Oster, Henrik, Astiz, Mariana
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2021
Materias:	Medicina Biología Circadian clock Mice Placenta Trophoblast Xenobiotic efflux transporter
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/142264
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-142264
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Medicina Biología Circadian clock Mice Placenta Trophoblast Xenobiotic efflux transporter
spellingShingle	Medicina Biología Circadian clock Mice Placenta Trophoblast Xenobiotic efflux transporter Demarez, Cécile Monteiro de Assis, Leonardo Vinícius Krohn, Markus Ramella, Nahuel Alberto Schwaninger, Markus Oster, Henrik Astiz, Mariana The trophoblast clock controls transport across placenta in mice
topic_facet	Medicina Biología Circadian clock Mice Placenta Trophoblast Xenobiotic efflux transporter
description	In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother.
format	Articulo Articulo
author	Demarez, Cécile Monteiro de Assis, Leonardo Vinícius Krohn, Markus Ramella, Nahuel Alberto Schwaninger, Markus Oster, Henrik Astiz, Mariana
author_facet	Demarez, Cécile Monteiro de Assis, Leonardo Vinícius Krohn, Markus Ramella, Nahuel Alberto Schwaninger, Markus Oster, Henrik Astiz, Mariana
author_sort	Demarez, Cécile
title	The trophoblast clock controls transport across placenta in mice
title_short	The trophoblast clock controls transport across placenta in mice
title_full	The trophoblast clock controls transport across placenta in mice
title_fullStr	The trophoblast clock controls transport across placenta in mice
title_full_unstemmed	The trophoblast clock controls transport across placenta in mice
title_sort	trophoblast clock controls transport across placenta in mice
publishDate	2021
url	http://sedici.unlp.edu.ar/handle/10915/142264
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bdutipo_str	Repositorios
_version_	1764820459175542784

The trophoblast clock controls transport across placenta in mice

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