Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention

Vanadium compounds are known for a variety of pharmacological properties. Many of them display antitumoral and osteogenic effects in several cell lines. Free radicals induce the development of tumoral processes. Natural polyphenols such as flavonoids have antioxidant properties since they scavenge d...

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Autores principales: Etcheverry, Susana Beatriz, Ferrer, Evelina Gloria, Naso, Luciana Gissella, Rivadeneira, Josefina, Salinas, María Victoria, Williams, Patricia Ana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/142249
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-142249
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
spellingShingle Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
Naso, Luciana Gissella
Rivadeneira, Josefina
Salinas, María Victoria
Williams, Patricia Ana María
Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
topic_facet Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
description Vanadium compounds are known for a variety of pharmacological properties. Many of them display antitumoral and osteogenic effects in several cell lines. Free radicals induce the development of tumoral processes. Natural polyphenols such as flavonoids have antioxidant properties since they scavenge different free radicals. For these reasons it is interesting to investigate the effects of a new complex generated between the vanadyl(IV) cation and the flavonoid hesperidin. The complex has been synthesized and characterized by physicochemical methods. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:VO and coordination by deprotonated cis-hydroxyl groups to the disaccharide moiety of the ligand. The complex improves the superoxide dismutase (SOD)-like activity of the ligand, but the scavenging of other radicals tested does not change upon complexation. When tested on two tumoral cell lines in culture (one of them derived from a rat osteosarcoma UMR106 and the other from human colon adenocarcinoma Caco-2), the complex enhanced the antiproliferative effects of the free ligand, and this effect correlated with the morphological alterations toward apoptosis. Also, on the osteoblastic cell line the complex stimulated cell proliferation and collagen type I production at low concentrations. At higher doses the complex behaved as a cytotoxic compound for the osteoblasts.
format Articulo
Articulo
author Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
Naso, Luciana Gissella
Rivadeneira, Josefina
Salinas, María Victoria
Williams, Patricia Ana María
author_facet Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
Naso, Luciana Gissella
Rivadeneira, Josefina
Salinas, María Victoria
Williams, Patricia Ana María
author_sort Etcheverry, Susana Beatriz
title Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_short Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_full Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_fullStr Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_full_unstemmed Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_sort antioxidant effects of the vo(iv) hesperidin complex and its role in cancer chemoprevention
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/142249
work_keys_str_mv AT etcheverrysusanabeatriz antioxidanteffectsofthevoivhesperidincomplexanditsroleincancerchemoprevention
AT ferrerevelinagloria antioxidanteffectsofthevoivhesperidincomplexanditsroleincancerchemoprevention
AT nasolucianagissella antioxidanteffectsofthevoivhesperidincomplexanditsroleincancerchemoprevention
AT rivadeneirajosefina antioxidanteffectsofthevoivhesperidincomplexanditsroleincancerchemoprevention
AT salinasmariavictoria antioxidanteffectsofthevoivhesperidincomplexanditsroleincancerchemoprevention
AT williamspatriciaanamaria antioxidanteffectsofthevoivhesperidincomplexanditsroleincancerchemoprevention
bdutipo_str Repositorios
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