Bioavailability study of paracetamol tablets in saliva and urine

A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution stud...

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Detalles Bibliográficos
Autores principales: Retaco, Patricia Alejandra, González, M., Pizzorno, María T., Volonté, María Guillermina
Formato: Articulo
Lenguaje:Inglés
Publicado: 1996
Materias:
Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/142040
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-142040
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
spellingShingle Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
Retaco, Patricia Alejandra
González, M.
Pizzorno, María T.
Volonté, María Guillermina
Bioavailability study of paracetamol tablets in saliva and urine
topic_facet Farmacia
Paracetamol
bioavailability
in vitro-in vivo correlation
description A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution study. Statistical evaluation of bioavailability parameters indicates that the two formulations may be considered bioequivalent, in spite of differences found during early stages of the absorption process, which were preventable according to an in vitro dissolution study.
format Articulo
Articulo
author Retaco, Patricia Alejandra
González, M.
Pizzorno, María T.
Volonté, María Guillermina
author_facet Retaco, Patricia Alejandra
González, M.
Pizzorno, María T.
Volonté, María Guillermina
author_sort Retaco, Patricia Alejandra
title Bioavailability study of paracetamol tablets in saliva and urine
title_short Bioavailability study of paracetamol tablets in saliva and urine
title_full Bioavailability study of paracetamol tablets in saliva and urine
title_fullStr Bioavailability study of paracetamol tablets in saliva and urine
title_full_unstemmed Bioavailability study of paracetamol tablets in saliva and urine
title_sort bioavailability study of paracetamol tablets in saliva and urine
publishDate 1996
url http://sedici.unlp.edu.ar/handle/10915/142040
work_keys_str_mv AT retacopatriciaalejandra bioavailabilitystudyofparacetamoltabletsinsalivaandurine
AT gonzalezm bioavailabilitystudyofparacetamoltabletsinsalivaandurine
AT pizzornomariat bioavailabilitystudyofparacetamoltabletsinsalivaandurine
AT volontemariaguillermina bioavailabilitystudyofparacetamoltabletsinsalivaandurine
bdutipo_str Repositorios
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