IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts

The aim of the present work was to evaluate the levels of anti-PGL-I and anti-10-kDa heat shock protein antibodies in serum and immune complexes isolated from leprosy patients, convivients and controls. Leprosy patients with erythema nodosum leprosum or without it were included and a comparative stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rojas, R. E., Demichelis, Sandra O., Sarno, E. N., Segal-Eiras, Amada
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	1997
Materias:	Ciencias Médicas Leprosy Erythema nodosum leprosum Immune complex Phenolic glycolipid I 10-kDa Heat shock protein
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/141456
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-141456
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Leprosy Erythema nodosum leprosum Immune complex Phenolic glycolipid I 10-kDa Heat shock protein
spellingShingle	Ciencias Médicas Leprosy Erythema nodosum leprosum Immune complex Phenolic glycolipid I 10-kDa Heat shock protein Rojas, R. E. Demichelis, Sandra O. Sarno, E. N. Segal-Eiras, Amada IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
topic_facet	Ciencias Médicas Leprosy Erythema nodosum leprosum Immune complex Phenolic glycolipid I 10-kDa Heat shock protein
description	The aim of the present work was to evaluate the levels of anti-PGL-I and anti-10-kDa heat shock protein antibodies in serum and immune complexes isolated from leprosy patients, convivients and controls. Leprosy patients with erythema nodosum leprosum or without it were included and a comparative study was done to investigate intergroup differences. Immune complexes were precipitated from serum by polyethylene glycol 3.5%; antibody levels were measured in sera and in dissociated immune complexes by ELISA. Serum antibody levels were then correlated with immune complex-associated antibody levels. The results showed that the erythema nodosum leprosum group differed from controls, contacts and non-erythema patients in their immune complex levels. IgM anti-PGL-I and IgG anti-10-kDa heat shock protein antibodies were constituents of the immune complexes in patients with erythema nodosum leprosum, who exhibited a significant difference in their immune complex composition compared with controls, contacts and non-erythema patients; while free antibody levels (anti-PGL-I and anti-10-kDa) did not differentiate between erythema and non-erythema patients, the measurement of immune complex-associated antibodies demonstrated a significant difference between the two clinical conditions. Furthermore, the measurement of immune complex-associated anti-PGL-I IgM made it possible to differentiate between contacts and controls. The significance of these results is discussed.
format	Articulo Articulo
author	Rojas, R. E. Demichelis, Sandra O. Sarno, E. N. Segal-Eiras, Amada
author_facet	Rojas, R. E. Demichelis, Sandra O. Sarno, E. N. Segal-Eiras, Amada
author_sort	Rojas, R. E.
title	IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
title_short	IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
title_full	IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
title_fullStr	IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
title_full_unstemmed	IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
title_sort	igm anti-phenolic glycolipid i and igg anti-10-kda heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
publishDate	1997
url	http://sedici.unlp.edu.ar/handle/10915/141456
work_keys_str_mv	AT rojasre igmantiphenolicglycolipidiandigganti10kdaheatshockproteinantibodiesinseraandimmunecomplexesisolatedfromleprosypatientswithorwithouterythemanodosumleprosumandcontacts AT demichelissandrao igmantiphenolicglycolipidiandigganti10kdaheatshockproteinantibodiesinseraandimmunecomplexesisolatedfromleprosypatientswithorwithouterythemanodosumleprosumandcontacts AT sarnoen igmantiphenolicglycolipidiandigganti10kdaheatshockproteinantibodiesinseraandimmunecomplexesisolatedfromleprosypatientswithorwithouterythemanodosumleprosumandcontacts AT segaleirasamada igmantiphenolicglycolipidiandigganti10kdaheatshockproteinantibodiesinseraandimmunecomplexesisolatedfromleprosypatientswithorwithouterythemanodosumleprosumandcontacts
bdutipo_str	Repositorios
_version_	1764820459101093891

IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts

Ejemplares similares