Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice

The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to...

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Autores principales: Minvielle, Marta Cecilia, Basualdo Farjat, Juan Ángel, Ciarmela, María Laura, Niedfeld, Germán
Formato: Articulo
Lenguaje:Inglés
Publicado: 1999
Materias:
Medicina
Toxocara canis
tinidazole
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/141455
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-141455
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Toxocara canis
tinidazole
spellingShingle Medicina
Toxocara canis
tinidazole
Minvielle, Marta Cecilia
Basualdo Farjat, Juan Ángel
Ciarmela, María Laura
Niedfeld, Germán
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
topic_facet Medicina
Toxocara canis
tinidazole
description The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.
format Articulo
Articulo
author Minvielle, Marta Cecilia
Basualdo Farjat, Juan Ángel
Ciarmela, María Laura
Niedfeld, Germán
author_facet Minvielle, Marta Cecilia
Basualdo Farjat, Juan Ángel
Ciarmela, María Laura
Niedfeld, Germán
author_sort Minvielle, Marta Cecilia
title Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_short Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_full Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_fullStr Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_full_unstemmed Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_sort anthelmintic efficacy of tinidazole against the progression of toxocara canis larvae to the brain in mice
publishDate 1999
url http://sedici.unlp.edu.ar/handle/10915/141455
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