Multi-target drug with potential applications: violacein in the spotlight

The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems...

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Detalles Bibliográficos
Autores principales: Durán, Nelson, Nakazato, Gerson, Durán, Marcela, Rivero Berti, Ignacio, Castro, Guillermo Raúl, Stanisic, Danijela, Brocchi, Marcelo, Fávaro, Wagner José, Ferreira-Halder, Carmen Veríssima, Justo, Giselle Z., Tasic, Ljubica
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/141055
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-141055
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
spellingShingle Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
Durán, Nelson
Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raúl
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner José
Ferreira-Halder, Carmen Veríssima
Justo, Giselle Z.
Tasic, Ljubica
Multi-target drug with potential applications: violacein in the spotlight
topic_facet Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
description The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.
format Articulo
Articulo
author Durán, Nelson
Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raúl
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner José
Ferreira-Halder, Carmen Veríssima
Justo, Giselle Z.
Tasic, Ljubica
author_facet Durán, Nelson
Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raúl
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner José
Ferreira-Halder, Carmen Veríssima
Justo, Giselle Z.
Tasic, Ljubica
author_sort Durán, Nelson
title Multi-target drug with potential applications: violacein in the spotlight
title_short Multi-target drug with potential applications: violacein in the spotlight
title_full Multi-target drug with potential applications: violacein in the spotlight
title_fullStr Multi-target drug with potential applications: violacein in the spotlight
title_full_unstemmed Multi-target drug with potential applications: violacein in the spotlight
title_sort multi-target drug with potential applications: violacein in the spotlight
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/141055
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