Can magnesium gluconate be used as an alternative therapy for preeclampsia?
Magnesium (Mg+2) in the body plays a structural and regulatory role and it is involved in fundamental cellular reactions. It is known that Mg+2 blood levels decrease during pregnancy, which has been related to preeclampsia and premature delivery, as well as other pathologies such as cardiovascular a...
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| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2022
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/140990 https://pmr.safisiol.org.ar/wp-content/uploads/2022/07/Vol-15-numero-4-2022.pdf |
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I19-R120-10915-140990 |
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dspace |
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Universidad Nacional de La Plata |
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I-19 |
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R-120 |
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SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Magnesium deficiency preeclampsia magnesium sulfate magnesium gluconate oxidative stress |
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Ciencias Médicas Magnesium deficiency preeclampsia magnesium sulfate magnesium gluconate oxidative stress Rangel, Heicher Abad, Cilia Chiarello, Delia I. Rojas, Deliana Proverbio, Fulgencio Marín, Reinaldo Can magnesium gluconate be used as an alternative therapy for preeclampsia? |
| topic_facet |
Ciencias Médicas Magnesium deficiency preeclampsia magnesium sulfate magnesium gluconate oxidative stress |
| description |
Magnesium (Mg+2) in the body plays a structural and regulatory role and it is involved in fundamental cellular reactions. It is known that Mg+2 blood levels decrease during pregnancy, which has been related to preeclampsia and premature delivery, as well as other pathologies such as cardiovascular alterations and renal, gastrointestinal, neurological, and muscular dysfunctions among others. Mg+2 salts are used to treat its deficiency, and parenteral magnesium sulfate (MgSO4) is relatively effective in preeclampsia and eclampsia. The use of MgSO4 has the main disadvantage that it is mainly administered intravenously which leads to significant toxicity risks. Currently, other magnesium salts are being studied as alternative treatments. Magnesium gluconate (Mg-gluconate) has been used to prevent pregnancy-induced hypertension, showing a greater antioxidant capacity than MgSO4. Mg-gluconate can scavenge hydroxyl and alkoxyl radicals and it has been shown that it can inhibit lipid peroxidation in microsomal membranes treated in vitro with the Fenton reaction. Mg-gluconate seems to be an excellent candidate to replace MgSO4 as a therapy for preeclampsia with severe features. |
| format |
Articulo Articulo |
| author |
Rangel, Heicher Abad, Cilia Chiarello, Delia I. Rojas, Deliana Proverbio, Fulgencio Marín, Reinaldo |
| author_facet |
Rangel, Heicher Abad, Cilia Chiarello, Delia I. Rojas, Deliana Proverbio, Fulgencio Marín, Reinaldo |
| author_sort |
Rangel, Heicher |
| title |
Can magnesium gluconate be used as an alternative therapy for preeclampsia? |
| title_short |
Can magnesium gluconate be used as an alternative therapy for preeclampsia? |
| title_full |
Can magnesium gluconate be used as an alternative therapy for preeclampsia? |
| title_fullStr |
Can magnesium gluconate be used as an alternative therapy for preeclampsia? |
| title_full_unstemmed |
Can magnesium gluconate be used as an alternative therapy for preeclampsia? |
| title_sort |
can magnesium gluconate be used as an alternative therapy for preeclampsia? |
| publishDate |
2022 |
| url |
http://sedici.unlp.edu.ar/handle/10915/140990 https://pmr.safisiol.org.ar/wp-content/uploads/2022/07/Vol-15-numero-4-2022.pdf |
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