Metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control
Pulmonary arterial hypertension (PAH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricular pressure overload and can lead to right-sided heart failure and death. A close link between PAH and cancer has been extensively suggested, with increasing evidence of a me...
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2022
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/140980 https://pmr.safisiol.org.ar/wp-content/uploads/2022/04/vol_15_numero_1__2022.pdf |
| Aporte de: |
| id |
I19-R120-10915-140980 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Pulmonary arterial hypertension right ventricular failure mitochondria oxidative stress metabolic shift apoptosis resistance |
| spellingShingle |
Ciencias Médicas Pulmonary arterial hypertension right ventricular failure mitochondria oxidative stress metabolic shift apoptosis resistance Nogueira de Alencar, Allan Kardec Ferreira Cruz, Fernanda Macedo Rocco, Patricia Rieken Leme Silva, Pedro Metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control |
| topic_facet |
Ciencias Médicas Pulmonary arterial hypertension right ventricular failure mitochondria oxidative stress metabolic shift apoptosis resistance |
| description |
Pulmonary arterial hypertension (PAH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricular pressure overload and can lead to right-sided heart failure and death. A close link between PAH and cancer has been extensively suggested, with increasing evidence of a metabolic theory that underlies the pathogenesis of both diseases, mainly due to similarities in the processes responsible for triggering a hyperproliferative and apoptosis-resistant phenotype in both cardiopulmonary and malignant cells. Similar to cancer, abnormalities in mitochondrial biogenesis might lead to the following consequences: dysfunction of this organelle, which, in turn, causes the Warburg effect, a shift from mitochondrial respiration toward glycolysis, culminating in mitophagy in diseased pulmonary vessels and right ventricular cardiomyocytes. The role of these mitochondrial abnormalities offers new therapeutic avenues. Therefore, this study reviews the bases of mitochondrial derangements in PAH and explores the therapeutic implications of mitochondrial dysfunction and metabolic disturbances in cells from the pulmonary vasculature and right ventricular myocardium by addressing promising and challenging areas of investigation. |
| format |
Articulo Articulo |
| author |
Nogueira de Alencar, Allan Kardec Ferreira Cruz, Fernanda Macedo Rocco, Patricia Rieken Leme Silva, Pedro |
| author_facet |
Nogueira de Alencar, Allan Kardec Ferreira Cruz, Fernanda Macedo Rocco, Patricia Rieken Leme Silva, Pedro |
| author_sort |
Nogueira de Alencar, Allan Kardec |
| title |
Metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control |
| title_short |
Metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control |
| title_full |
Metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control |
| title_fullStr |
Metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control |
| title_full_unstemmed |
Metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control |
| title_sort |
metabolic theory of pulmonary arterial hypertension: connecting mitochondrial roles with disease control |
| publishDate |
2022 |
| url |
http://sedici.unlp.edu.ar/handle/10915/140980 https://pmr.safisiol.org.ar/wp-content/uploads/2022/04/vol_15_numero_1__2022.pdf |
| work_keys_str_mv |
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Repositorios |
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