Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica

Mannheimia haemolytica is the main bacterial pathogen isolated in bovine respiratory disease (BRD), a common disease affecting calves before weaning. Previous research has shown that experimental infection with bovine herpesvirus 1, a respiratory virus, decreases plasma zinc (Zn) levels. However, ch...

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Detalles Bibliográficos
Autores principales: Galarza, Esteban Martín, Lizarraga, Raúl Martín, Streitenberger, Nicolás, Arriaga, Guido José, Abraham, Mattioli, Guillermo Alberto, Anchordoquy, Juan Mateo, Fazzio, Luis Emilio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Veterinaria
Ciencias Naturales
Micronutrient
Cattle
Mannheimia haemolytica
Total leukocyte count
Bovine respiratory disease
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/140837
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-140837
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Veterinaria
Ciencias Naturales
Micronutrient
Cattle
Mannheimia haemolytica
Total leukocyte count
Bovine respiratory disease
spellingShingle Veterinaria
Ciencias Naturales
Micronutrient
Cattle
Mannheimia haemolytica
Total leukocyte count
Bovine respiratory disease
Galarza, Esteban Martín
Lizarraga, Raúl Martín
Streitenberger, Nicolás
Arriaga, Guido José
Abraham,
Mattioli, Guillermo Alberto
Anchordoquy, Juan Mateo
Fazzio, Luis Emilio
Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica
topic_facet Veterinaria
Ciencias Naturales
Micronutrient
Cattle
Mannheimia haemolytica
Total leukocyte count
Bovine respiratory disease
description Mannheimia haemolytica is the main bacterial pathogen isolated in bovine respiratory disease (BRD), a common disease affecting calves before weaning. Previous research has shown that experimental infection with bovine herpesvirus 1, a respiratory virus, decreases plasma zinc (Zn) levels. However, changes in plasma Zn concentrations in calves experimentally infected with M. haemolytica have not been studied thus far. The objective of this study was to evaluate the effect of experimental infection with M. haemolytica on plasma Zn concentration in calves. Total leukocyte count and bovine respiratory disease (BRD) clinical score were also evaluated. We conducted a 6-day trial in 14 male Holstein calves randomly assigned to one of two groups, experimental (EG, n = 8) and control (CG, n = 6). Animals in EG were intrabronchially inoculated with M. haemolytica (6.5 × 106 CFU/mL) on day 0 of the trial. Plasma Zn levels were affected by time, treatment, and time by treatment interaction, being lower in EG compared with CG on days 1, 2, and 3. Differences in total leukocyte count were significant on day 1, observing a tendency on day 3. BRD clinical score differed between groups, being higher in EG throughout the trial. We conclude that experimental M. haemolytica infection reduced plasma Zn concentration in clinically ill calves, suggesting that the clinical condition of animals (healthy/ill) should be considered to better interpret plasma Zn values.
format Articulo
Articulo
author Galarza, Esteban Martín
Lizarraga, Raúl Martín
Streitenberger, Nicolás
Arriaga, Guido José
Abraham,
Mattioli, Guillermo Alberto
Anchordoquy, Juan Mateo
Fazzio, Luis Emilio
author_facet Galarza, Esteban Martín
Lizarraga, Raúl Martín
Streitenberger, Nicolás
Arriaga, Guido José
Abraham,
Mattioli, Guillermo Alberto
Anchordoquy, Juan Mateo
Fazzio, Luis Emilio
author_sort Galarza, Esteban Martín
title Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica
title_short Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica
title_full Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica
title_fullStr Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica
title_full_unstemmed Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica
title_sort assessment of plasma zinc and total leukocyte count in calves experimentally infected with mannheimia haemolytica
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/140837
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