The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase

The inhibitory effect of vanadate species on the enzymatic activity of bovine copper-zinc superoxide dismutase has been investigated at different pH values and vanadium concentrations. A definite inhibitory effect, clearly related to the main negative charge of each of the vanadate solutions, has be...

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Detalles Bibliográficos
Autores principales: Apella, María Cristina, González, Silvia Nelina, Baran, Enrique José
Formato: Articulo
Lenguaje:Inglés
Publicado: 1988
Materias:
Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/140438
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-140438
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
spellingShingle Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
Apella, María Cristina
González, Silvia Nelina
Baran, Enrique José
The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
topic_facet Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
description The inhibitory effect of vanadate species on the enzymatic activity of bovine copper-zinc superoxide dismutase has been investigated at different pH values and vanadium concentrations. A definite inhibitory effect, clearly related to the main negative charge of each of the vanadate solutions, has been found. The results suggest that the origin of the inhibitory effect may be similar to that found for the phosphate ion, i.e., a diminution of the effectiveness of the substrate electronic guidance mechanism by partial neutralization of the charges close to the active site. Under physiological conditions, the inhibitory effect of vanadate is somewhat smaller than the phosphate.
format Articulo
Articulo
author Apella, María Cristina
González, Silvia Nelina
Baran, Enrique José
author_facet Apella, María Cristina
González, Silvia Nelina
Baran, Enrique José
author_sort Apella, María Cristina
title The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_short The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_full The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_fullStr The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_full_unstemmed The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_sort inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
publishDate 1988
url http://sedici.unlp.edu.ar/handle/10915/140438
work_keys_str_mv AT apellamariacristina theinhibitoryeffectofvanadiumoxoanionsontheactivityofcopperzincsuperoxidedismutase
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