The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP...

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Detalles Bibliográficos
Autores principales: Vittone, Leticia Beatriz, Chiappe, Liliana Eusebia, Argel, María Isabel, Cingolani, Horacio Eugenio, Chiappe de Cingolani, Gladys Ethel
Formato: Articulo
Lenguaje:Inglés
Publicado: 1980
Materias:
Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139565
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

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