The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP...

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Autores principales: Vittone, Leticia Beatriz, Chiappe, Liliana Eusebia, Argel, María Isabel, Cingolani, Horacio Eugenio, Chiappe de Cingolani, Gladys Ethel
Formato: Articulo
Lenguaje:Inglés
Publicado: 1980
Materias:
Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139565
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-139565
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
spellingShingle Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
Vittone, Leticia Beatriz
Chiappe, Liliana Eusebia
Argel, María Isabel
Cingolani, Horacio Eugenio
Chiappe de Cingolani, Gladys Ethel
The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
topic_facet Medicina
Nucleotide
Protein Kinase
Kinase Activity
Maximum Rate
Phosphodiesterase
description Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
format Articulo
Articulo
author Vittone, Leticia Beatriz
Chiappe, Liliana Eusebia
Argel, María Isabel
Cingolani, Horacio Eugenio
Chiappe de Cingolani, Gladys Ethel
author_facet Vittone, Leticia Beatriz
Chiappe, Liliana Eusebia
Argel, María Isabel
Cingolani, Horacio Eugenio
Chiappe de Cingolani, Gladys Ethel
author_sort Vittone, Leticia Beatriz
title The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_short The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_full The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_fullStr The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_full_unstemmed The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
title_sort mechanical and biochemical effects of pentoxifylline on the perfused rat heart
publishDate 1980
url http://sedici.unlp.edu.ar/handle/10915/139565
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