Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects

Ghrelin is a stomach-derived peptide hormone with salient roles in the regulation of energy balance and metabolism. Notably, ghrelin is recognized as the most powerful known circulating orexigenic hormone. Here, we systematically investigated the effects of ghrelin on energy homeostasis and found th...

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Detalles Bibliográficos
Autores principales: Cornejo, María Paula, Denis, Raphaël G. P., García Romero, Guadalupe, Fernández, Gimena, Reynaldo, Mirta Beatriz, Luquet, Serge, Perelló, Mario Carlos
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139526
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-139526
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
spellingShingle Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
Cornejo, María Paula
Denis, Raphaël G. P.
García Romero, Guadalupe
Fernández, Gimena
Reynaldo, Mirta Beatriz
Luquet, Serge
Perelló, Mario Carlos
Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
topic_facet Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
description Ghrelin is a stomach-derived peptide hormone with salient roles in the regulation of energy balance and metabolism. Notably, ghrelin is recognized as the most powerful known circulating orexigenic hormone. Here, we systematically investigated the effects of ghrelin on energy homeostasis and found that ghrelin primarily induces a biphasic effect on food intake that has indirect consequences on energy expenditure and nutrient partitioning. We also found that ghrelin-induced biphasic effect on food intake requires the integrity of Agouti-related peptide/neuropeptide Y-producing neurons of the hypothalamic arcuate nucleus, which seem to display a long-lasting activation after a single systemic injection of ghrelin. Finally, we found that different autonomic, hormonal and metabolic satiation signals transiently counteract ghrelin-induced food intake. Based on our observations, we propose a heuristic model to describe how the orexigenic effect of ghrelin and the anorectic food intake-induced rebound sculpt a timely constrain feeding response to ghrelin.
format Articulo
Articulo
author Cornejo, María Paula
Denis, Raphaël G. P.
García Romero, Guadalupe
Fernández, Gimena
Reynaldo, Mirta Beatriz
Luquet, Serge
Perelló, Mario Carlos
author_facet Cornejo, María Paula
Denis, Raphaël G. P.
García Romero, Guadalupe
Fernández, Gimena
Reynaldo, Mirta Beatriz
Luquet, Serge
Perelló, Mario Carlos
author_sort Cornejo, María Paula
title Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_short Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_full Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_fullStr Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_full_unstemmed Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_sort ghrelin treatment induces rapid and delayed increments of food intake : a heuristic model to explain ghrelin's orexigenic effects
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/139526
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