Assessment of Cu-Zn EDTA Parenteral Toxicity in Calves

Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable C...

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Autores principales: Fazzio, Luis Emilio, Rosa, Diana Esther, Picco, Sebastián Julio, Mattioli, Guillermo Alberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Veterinaria
Copper
Zinc
Liver damage
Cattle
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139208
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-139208
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Veterinaria
Copper
Zinc
Liver damage
Cattle
spellingShingle Veterinaria
Copper
Zinc
Liver damage
Cattle
Fazzio, Luis Emilio
Rosa, Diana Esther
Picco, Sebastián Julio
Mattioli, Guillermo Alberto
Assessment of Cu-Zn EDTA Parenteral Toxicity in Calves
topic_facet Veterinaria
Copper
Zinc
Liver damage
Cattle
description Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Zn EDTA appears as an alternative; however, data about its toxicity is unknown. The aim of this study was to assess toxicity risk of different doses of Cu-Zn EDTA in calves. Thirty two Aberdeen Angus calves of 162 (±20) kg BW were assigned to 4 groups (n = 8), homogeneous in weight, sex, and age. Cu-Zn EDTA was administrated in doses of 0.3 mg/kg BW (group 1X); 0.6 mg/kg BW (group 2X); 0.9 mg/kg BW (group 3X) and sterile saline solution (control group-with no treatment). Clinical and blood parameters in animals were monitored during 28 days. In groups' control, 1X and 2X there were no alterations in the assessed parameters. In group 3X, one of the animals showed depression, permanent decubitus, and muscular twitching; that animal had to be killed in extremis for humanitarian reasons. Necropsy and Cu tissue concentration findings confirmed intoxication in the clinically affected animal. The rest of the animals in group 3X showed only a temporary increase in liver enzymes. The results indicate that a dose of 0.9 mg/kg BW of Cu as Cu-Zn EDTA is potentially hepatotoxic, this dose is similar to other soluble salts of parenteral administration.
format Articulo
Articulo
author Fazzio, Luis Emilio
Rosa, Diana Esther
Picco, Sebastián Julio
Mattioli, Guillermo Alberto
author_facet Fazzio, Luis Emilio
Rosa, Diana Esther
Picco, Sebastián Julio
Mattioli, Guillermo Alberto
author_sort Fazzio, Luis Emilio
title Assessment of Cu-Zn EDTA Parenteral Toxicity in Calves
title_short Assessment of Cu-Zn EDTA Parenteral Toxicity in Calves
title_full Assessment of Cu-Zn EDTA Parenteral Toxicity in Calves
title_fullStr Assessment of Cu-Zn EDTA Parenteral Toxicity in Calves
title_full_unstemmed Assessment of Cu-Zn EDTA Parenteral Toxicity in Calves
title_sort assessment of cu-zn edta parenteral toxicity in calves
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/139208
work_keys_str_mv AT fazzioluisemilio assessmentofcuznedtaparenteraltoxicityincalves
AT rosadianaesther assessmentofcuznedtaparenteraltoxicityincalves
AT piccosebastianjulio assessmentofcuznedtaparenteraltoxicityincalves
AT mattioliguillermoalberto assessmentofcuznedtaparenteraltoxicityincalves
bdutipo_str Repositorios
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