The oxidative desaturation of unsaturated fatty acids in animals

The progress made in the knowledge of the microsomal fatty acid desaturation reaction is described: 1) Studies suggest that different enzymes produce 9, 6, and 5-desaturation. 2) The 6-desaturation of fatty acids would be the principal regulatory step in the biosynthesis of polyunsaturated fatty aci...

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Detalles Bibliográficos
Autor principal: Brenner, Rodolfo Roberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 1974
Materias:
Química
Medicina
Sucrose
Glucose Metabolism
Polyunsaturated Fatty Acid
Unsaturated Fatty Acid
Sucrose Solution
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139148
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-139148
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Medicina
Sucrose
Glucose Metabolism
Polyunsaturated Fatty Acid
Unsaturated Fatty Acid
Sucrose Solution
spellingShingle Química
Medicina
Sucrose
Glucose Metabolism
Polyunsaturated Fatty Acid
Unsaturated Fatty Acid
Sucrose Solution
Brenner, Rodolfo Roberto
The oxidative desaturation of unsaturated fatty acids in animals
topic_facet Química
Medicina
Sucrose
Glucose Metabolism
Polyunsaturated Fatty Acid
Unsaturated Fatty Acid
Sucrose Solution
description The progress made in the knowledge of the microsomal fatty acid desaturation reaction is described: 1) Studies suggest that different enzymes produce 9, 6, and 5-desaturation. 2) The 6-desaturation of fatty acids would be the principal regulatory step in the biosynthesis of polyunsaturated fatty acids in rat microsomes. 3) The desaturation of fatty acids is quantitatively modified by competitive reactions among acids of the same or different families, and by competition with fatty acid incorporation in the lipids. 4) Dietary components, especially carbohydrates and protein modify quantitatively the fatty acid desaturation. Protein would induce the 6-desaturation reaction. 5) Insulin modifies the 6-desaturation reaction through a dual effect: one modifying glucose metabolism, and the other through enzymatic induction. 6) ATP increases the 6-desaturation of fatty acids 7) By mild extraction of the microsomes with buffered KCl sucrose solution, a “soluble” fraction was separated that was necessary for a full desaturation activity of the microsomes. The nature of this factor is discussed. 8) The main features that characterize the 6-desaturation reaction are discussed and the possible structure of the enzyme outlined.
format Articulo
Articulo
author Brenner, Rodolfo Roberto
author_facet Brenner, Rodolfo Roberto
author_sort Brenner, Rodolfo Roberto
title The oxidative desaturation of unsaturated fatty acids in animals
title_short The oxidative desaturation of unsaturated fatty acids in animals
title_full The oxidative desaturation of unsaturated fatty acids in animals
title_fullStr The oxidative desaturation of unsaturated fatty acids in animals
title_full_unstemmed The oxidative desaturation of unsaturated fatty acids in animals
title_sort oxidative desaturation of unsaturated fatty acids in animals
publishDate 1974
url http://sedici.unlp.edu.ar/handle/10915/139148
work_keys_str_mv AT brennerrodolforoberto theoxidativedesaturationofunsaturatedfattyacidsinanimals
AT brennerrodolforoberto oxidativedesaturationofunsaturatedfattyacidsinanimals
bdutipo_str Repositorios
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