Pediatric Clinical Pharmacology Studies in Chagas Disease

Chagas disease is a neglected parasitic disease endemic in the Americas. It mainly affects impoverished populations and the acute phase of the infection mostly affects children. Many cases have also been detected in nonendemic countries as a result of recent migratory trends. The chronic phase is re...

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Autores principales: Garcia Bournissen, Facundo, Altcheh, Jaime, Giglio, Norberto, Mastrantonio, Guido, Della Védova, Carlos Omar, Koren, Gideon
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Medicina
Farmacia
Chagas disease
benznidazole
pediatric population
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138817
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-138817
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Farmacia
Chagas disease
benznidazole
pediatric population
spellingShingle Medicina
Farmacia
Chagas disease
benznidazole
pediatric population
Garcia Bournissen, Facundo
Altcheh, Jaime
Giglio, Norberto
Mastrantonio, Guido
Della Védova, Carlos Omar
Koren, Gideon
Pediatric Clinical Pharmacology Studies in Chagas Disease
topic_facet Medicina
Farmacia
Chagas disease
benznidazole
pediatric population
description Chagas disease is a neglected parasitic disease endemic in the Americas. It mainly affects impoverished populations and the acute phase of the infection mostly affects children. Many cases have also been detected in nonendemic countries as a result of recent migratory trends. The chronic phase is relatively asymptomatic, but 30% of patients with chronic infection eventually develop cardiac and digestive complications that commonly lead to death or disability. Only two drugs are available for the treatment of Chagas disease, benznidazole and nifurtimox. These drugs have been shown to be effective in the treatment of both acute and early chronic phases in children, but the pharmacokinetics of these drugs have never been studied in this population. We have set out to conduct a pharmacokinetics study of benznidazole in a pediatric population with Chagas disease. The results of this study are expected to allow better estimation of the optimal doses and schedule of pharmacotherapy for Chagas disease in children.
format Articulo
Articulo
author Garcia Bournissen, Facundo
Altcheh, Jaime
Giglio, Norberto
Mastrantonio, Guido
Della Védova, Carlos Omar
Koren, Gideon
author_facet Garcia Bournissen, Facundo
Altcheh, Jaime
Giglio, Norberto
Mastrantonio, Guido
Della Védova, Carlos Omar
Koren, Gideon
author_sort Garcia Bournissen, Facundo
title Pediatric Clinical Pharmacology Studies in Chagas Disease
title_short Pediatric Clinical Pharmacology Studies in Chagas Disease
title_full Pediatric Clinical Pharmacology Studies in Chagas Disease
title_fullStr Pediatric Clinical Pharmacology Studies in Chagas Disease
title_full_unstemmed Pediatric Clinical Pharmacology Studies in Chagas Disease
title_sort pediatric clinical pharmacology studies in chagas disease
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/138817
work_keys_str_mv AT garciabournissenfacundo pediatricclinicalpharmacologystudiesinchagasdisease
AT altchehjaime pediatricclinicalpharmacologystudiesinchagasdisease
AT giglionorberto pediatricclinicalpharmacologystudiesinchagasdisease
AT mastrantonioguido pediatricclinicalpharmacologystudiesinchagasdisease
AT dellavedovacarlosomar pediatricclinicalpharmacologystudiesinchagasdisease
AT korengideon pediatricclinicalpharmacologystudiesinchagasdisease
bdutipo_str Repositorios
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