Intestinal epithelial barrier and mucosal immunity

Intestinal mucosa integrates primary digestive functions with immune functions such as pathogen surveillance, antigen transport and induction of mucosal immunity and tolerance. Intestinal adaptive immunity is elicited in organized mucosa-associated lymphoid tissue (O-MALT) that is composed of antige...

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Detalles Bibliográficos
Autores principales: Rumbo, Martín, Schiffrin, Eduardo J.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2005
Materias:
Ciencias Exactas
Human intestine
innate immunity
epithelium
development
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138686
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-138686
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Human intestine
innate immunity
epithelium
development
spellingShingle Ciencias Exactas
Human intestine
innate immunity
epithelium
development
Rumbo, Martín
Schiffrin, Eduardo J.
Intestinal epithelial barrier and mucosal immunity
topic_facet Ciencias Exactas
Human intestine
innate immunity
epithelium
development
description Intestinal mucosa integrates primary digestive functions with immune functions such as pathogen surveillance, antigen transport and induction of mucosal immunity and tolerance. Intestinal adaptive immunity is elicited in organized mucosa-associated lymphoid tissue (O-MALT) that is composed of antigen-presenting cells and lymphocytes and achieved by effector cells widely distributed in mucosa (diffuse MALT or D-MALT). Interaction between the intestinal epithelium, the O-MALT and the diffuse MALT plays a critical role in establishing an adequate immune response. In regions associated to O-MALT, lympho-epithelial cross-talks lead to acquisition of a specific epithelial phenotype that contributes to O-MALT organization and functionality. Beyond the expression of several innate immune functions, the intestinal epithelium may directly take up and present antigens due to the expression of major histocompatibility complex (MHC) and MHC-related molecules. A complex genetic program that will be outlined in the present review controls the development of immune functions of the intestinal epithelium. The effect of environmental signals on the modulation of this ontogenetic program during development and neonatal life, from bioactive components of amniotic fluid to lactation and bacterial colonization, will be discussed.
format Articulo
Articulo
author Rumbo, Martín
Schiffrin, Eduardo J.
author_facet Rumbo, Martín
Schiffrin, Eduardo J.
author_sort Rumbo, Martín
title Intestinal epithelial barrier and mucosal immunity
title_short Intestinal epithelial barrier and mucosal immunity
title_full Intestinal epithelial barrier and mucosal immunity
title_fullStr Intestinal epithelial barrier and mucosal immunity
title_full_unstemmed Intestinal epithelial barrier and mucosal immunity
title_sort intestinal epithelial barrier and mucosal immunity
publishDate 2005
url http://sedici.unlp.edu.ar/handle/10915/138686
work_keys_str_mv AT rumbomartin intestinalepithelialbarrierandmucosalimmunity
AT schiffrineduardoj intestinalepithelialbarrierandmucosalimmunity
bdutipo_str Repositorios
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