Gene target discovery with network analysis in Toxoplasma gondii

Infectious diseases are of great relevance for global health, but needed drugs and vaccines have not been developed yet or are not effective in many cases. In fact, traditional scientific approaches with intense focus on individual genes or proteins have not been successful in providing new treatmen...

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Detalles Bibliográficos
Autores principales:	Alonso, Andrés Mariano, Corvi, Maria M., Diambra, Luis Aníbal
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2019
Materias:	Ciencias Exactas Biología Toxoplasma gondii pathogen biology network analysis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/138645
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-138645
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Biología Toxoplasma gondii pathogen biology network analysis
spellingShingle	Ciencias Exactas Biología Toxoplasma gondii pathogen biology network analysis Alonso, Andrés Mariano Corvi, Maria M. Diambra, Luis Aníbal Gene target discovery with network analysis in Toxoplasma gondii
topic_facet	Ciencias Exactas Biología Toxoplasma gondii pathogen biology network analysis
description	Infectious diseases are of great relevance for global health, but needed drugs and vaccines have not been developed yet or are not effective in many cases. In fact, traditional scientific approaches with intense focus on individual genes or proteins have not been successful in providing new treatments. Hence, innovations in technology and computational methods provide new tools to further understand complex biological systems such as pathogens biology. In this work, we propose a system biology approach to analyze transcriptomic data of the parasite Toxoplasma gondii . By means of an optimization procedure, the phenotypic transitions between the stages associated with the life cycle of the parasite were embedded into the dynamics of a gene network model. Thus, through this methodology we were able to reconstruct a gene regulatory network able to emulate the life cycle of the pathogen. The community network analysis has revealed that nodes of the network can be organized in seven communities which allow us to assign putative functions to 339 previously uncharacterized genes, 25 of which are predicted as new pathogenic factors. Furthermore, we identified a small subnetwork module that controls the parasite9s life cycle. These new findings can contribute to understand of parasite pathogenesis.
format	Articulo Articulo
author	Alonso, Andrés Mariano Corvi, Maria M. Diambra, Luis Aníbal
author_facet	Alonso, Andrés Mariano Corvi, Maria M. Diambra, Luis Aníbal
author_sort	Alonso, Andrés Mariano
title	Gene target discovery with network analysis in Toxoplasma gondii
title_short	Gene target discovery with network analysis in Toxoplasma gondii
title_full	Gene target discovery with network analysis in Toxoplasma gondii
title_fullStr	Gene target discovery with network analysis in Toxoplasma gondii
title_full_unstemmed	Gene target discovery with network analysis in Toxoplasma gondii
title_sort	gene target discovery with network analysis in toxoplasma gondii
publishDate	2019
url	http://sedici.unlp.edu.ar/handle/10915/138645
work_keys_str_mv	AT alonsoandresmariano genetargetdiscoverywithnetworkanalysisintoxoplasmagondii AT corvimariam genetargetdiscoverywithnetworkanalysisintoxoplasmagondii AT diambraluisanibal genetargetdiscoverywithnetworkanalysisintoxoplasmagondii
bdutipo_str	Repositorios
_version_	1764820457672933376

Gene target discovery with network analysis in Toxoplasma gondii

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