Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats

Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date,...

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Detalles Bibliográficos
Autores principales: Pallarés, María Eugenia, Monteleone, Melisa Carolina, Pastor, Verónica Estela, Grillo Balboa, Jazmín, Alzamendi, Ana, Brocco, Marcela Adriana, Antonelli, Marta Cristina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138540
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-138540
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
spellingShingle Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
Pallarés, María Eugenia
Monteleone, Melisa Carolina
Pastor, Verónica Estela
Grillo Balboa, Jazmín
Alzamendi, Ana
Brocco, Marcela Adriana
Antonelli, Marta Cristina
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
topic_facet Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
description Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of <i>bdnf</i>-IV and <i>crfr1</i> and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders.
format Articulo
Articulo
author Pallarés, María Eugenia
Monteleone, Melisa Carolina
Pastor, Verónica Estela
Grillo Balboa, Jazmín
Alzamendi, Ana
Brocco, Marcela Adriana
Antonelli, Marta Cristina
author_facet Pallarés, María Eugenia
Monteleone, Melisa Carolina
Pastor, Verónica Estela
Grillo Balboa, Jazmín
Alzamendi, Ana
Brocco, Marcela Adriana
Antonelli, Marta Cristina
author_sort Pallarés, María Eugenia
title Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_short Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_full Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_fullStr Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_full_unstemmed Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_sort early-life stress reprograms stress-coping abilities in male and female juvenile rats
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/138540
work_keys_str_mv AT pallaresmariaeugenia earlylifestressreprogramsstresscopingabilitiesinmaleandfemalejuvenilerats
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bdutipo_str Repositorios
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