Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger

In this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy.We propose that t...

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Autores principales: Cingolani, Horacio Eugenio, Pérez, Néstor Gustavo, Caldiz, Claudia Irma, Garciarena, Carolina Denis, De Giusti, Verónica Celeste, Correa, María Verónica, Villa Abrille, María Celeste, Yeves, Alejandra del Milagro, Ennis, Irene Lucía, Chiappe de Cingolani, Gladys Ethel, Aiello, Ernesto Alejandro, Kamkin, Andre, Kiseleva, Irina
Formato: Libro Capitulo de libro
Lenguaje:Inglés
Publicado: Springer 2010
Materias:
Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138476
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-138476
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
spellingShingle Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Caldiz, Claudia Irma
Garciarena, Carolina Denis
De Giusti, Verónica Celeste
Correa, María Verónica
Villa Abrille, María Celeste
Yeves, Alejandra del Milagro
Ennis, Irene Lucía
Chiappe de Cingolani, Gladys Ethel
Aiello, Ernesto Alejandro
Kamkin, Andre
Kiseleva, Irina
Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
topic_facet Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
description In this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy.We propose that the chain of events triggered by stretch begins with the release of small amounts of angiotensin II which in turn induce the release/formation of endothelin. The actions of these hormones trigger the production of mitochondrial reactive oxygen species that enhances NHE-1 activity, causing an increment in the intracellular Na+ concentration which promotes the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger. This [Ca2+]i increase would trigger cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.
format Libro
Capitulo de libro
author Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Caldiz, Claudia Irma
Garciarena, Carolina Denis
De Giusti, Verónica Celeste
Correa, María Verónica
Villa Abrille, María Celeste
Yeves, Alejandra del Milagro
Ennis, Irene Lucía
Chiappe de Cingolani, Gladys Ethel
Aiello, Ernesto Alejandro
Kamkin, Andre
Kiseleva, Irina
author_facet Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Caldiz, Claudia Irma
Garciarena, Carolina Denis
De Giusti, Verónica Celeste
Correa, María Verónica
Villa Abrille, María Celeste
Yeves, Alejandra del Milagro
Ennis, Irene Lucía
Chiappe de Cingolani, Gladys Ethel
Aiello, Ernesto Alejandro
Kamkin, Andre
Kiseleva, Irina
author_sort Cingolani, Horacio Eugenio
title Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_short Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_full Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_fullStr Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_full_unstemmed Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_sort early hypertrophic signals after myocardial stretch : role of reactive oxygen species and the sodium/hydrogen exchanger
publisher Springer
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/138476
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