Nature of changes in adrenocortical function in chronic hyperleptinemic female rats

Neonatal treatment of rats with monosodium l-glutamate, which destroys hypothalamic arcuate nucleus neuronal bodies, induces several metabolic abnormalities; as a result, rats develop a phenotype of pseudoobesity. This study was designed to explore, in the monosodium l-glutamate-treated female rat,...

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Autores principales: Perelló, Mario Carlos, Moreno, Griselda Noemí, Camihort, Gisela Amelia, Luna, Georgina Cecilia, Console-Avegliano, Gloria Miriam, Gaillard, Rolf C., Spinedi, Eduardo Julio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2004
Materias:
Bioquímica
:ARC damage
Hypothalamic obesity
Positive energetic balance
Ob-Rb
Adiposity
Adrenal gland
Glucocorticoid
Leptin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138342
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-138342
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
:ARC damage
Hypothalamic obesity
Positive energetic balance
Ob-Rb
Adiposity
Adrenal gland
Glucocorticoid
Leptin
spellingShingle Bioquímica
:ARC damage
Hypothalamic obesity
Positive energetic balance
Ob-Rb
Adiposity
Adrenal gland
Glucocorticoid
Leptin
Perelló, Mario Carlos
Moreno, Griselda Noemí
Camihort, Gisela Amelia
Luna, Georgina Cecilia
Console-Avegliano, Gloria Miriam
Gaillard, Rolf C.
Spinedi, Eduardo Julio
Nature of changes in adrenocortical function in chronic hyperleptinemic female rats
topic_facet Bioquímica
:ARC damage
Hypothalamic obesity
Positive energetic balance
Ob-Rb
Adiposity
Adrenal gland
Glucocorticoid
Leptin
description Neonatal treatment of rats with monosodium l-glutamate, which destroys hypothalamic arcuate nucleus neuronal bodies, induces several metabolic abnormalities; as a result, rats develop a phenotype of pseudoobesity. This study was designed to explore, in the monosodium l-glutamate-treated female rat, the influence of chronic hyperleptinemia on adrenal cortex functionality. For this purpose, we evaluated in control and hypothalamic-damaged rats: (a) in vivo and in vitro adrenocortical function, (b) adrenal leptin receptor immunodistribution and mRNA expression, and (c) whether the inhibitory effect of leptin on adrenal function remains. Our results indicate that, compared to normal counterparts, pseudoobese animals displayed (1) hyperadiposity, despite being hypophagic and of lower body weight, (2) in vivo and in vitro enhanced adrenocortical response to ACTH stimulation, (3) an in vitro adrenal fasciculata-reticularis cell hyper-sensitivity to ACTH stimulus, (4) hyperplasia of their adrenal zona fasciculata cells, and (5) adrenal fasciculata-reticularis cell refractoriness to the inhibitory effect of leptin on ACTH-stimulated glucocorticoid production due, at least in part, to decreased adrenal leptin receptor expression. These data further support that increased hypothalamo-pituitary-adrenal axis function, in the adult neurotoxin-lesioned female rat, is mainly dependent on the development of both hyperplasia of adrenal zona fasciculata and adrenal gland refractoriness to leptin inhibitory effect. Our study supports that adrenal leptin resistance could be responsible, at least in part, for enhanced glucocorticoid circulating levels in this phenotype of obesity.
format Articulo
Articulo
author Perelló, Mario Carlos
Moreno, Griselda Noemí
Camihort, Gisela Amelia
Luna, Georgina Cecilia
Console-Avegliano, Gloria Miriam
Gaillard, Rolf C.
Spinedi, Eduardo Julio
author_facet Perelló, Mario Carlos
Moreno, Griselda Noemí
Camihort, Gisela Amelia
Luna, Georgina Cecilia
Console-Avegliano, Gloria Miriam
Gaillard, Rolf C.
Spinedi, Eduardo Julio
author_sort Perelló, Mario Carlos
title Nature of changes in adrenocortical function in chronic hyperleptinemic female rats
title_short Nature of changes in adrenocortical function in chronic hyperleptinemic female rats
title_full Nature of changes in adrenocortical function in chronic hyperleptinemic female rats
title_fullStr Nature of changes in adrenocortical function in chronic hyperleptinemic female rats
title_full_unstemmed Nature of changes in adrenocortical function in chronic hyperleptinemic female rats
title_sort nature of changes in adrenocortical function in chronic hyperleptinemic female rats
publishDate 2004
url http://sedici.unlp.edu.ar/handle/10915/138342
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