Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.

Pathological studies were carried out on the lungs of guinea pigs intratracheally inoculated with 4.6 × 106-8 colony forming units (CFU)/head of Actinobacillus pleuropneumoniae serovar 1. All animals in the highest dose group died within 24 hr post inoculation (hpi) and showed pulmonary lesions bein...

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Autores principales: Perfumo, Carlos Juan, Petruccelli, Miguel Ángel, Itagaki, Shin-ichi
Formato: Articulo
Lenguaje:Inglés
Publicado: 1999
Materias:
Veterinaria
Biología
Actinobacillus pleuropneumoniae serovar 1
fibrinonecrotic pleuropneumonia
guinea pig
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137823
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137823
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Veterinaria
Biología
Actinobacillus pleuropneumoniae serovar 1
fibrinonecrotic pleuropneumonia
guinea pig
spellingShingle Veterinaria
Biología
Actinobacillus pleuropneumoniae serovar 1
fibrinonecrotic pleuropneumonia
guinea pig
Perfumo, Carlos Juan
Petruccelli, Miguel Ángel
Itagaki, Shin-ichi
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.
topic_facet Veterinaria
Biología
Actinobacillus pleuropneumoniae serovar 1
fibrinonecrotic pleuropneumonia
guinea pig
description Pathological studies were carried out on the lungs of guinea pigs intratracheally inoculated with 4.6 × 106-8 colony forming units (CFU)/head of Actinobacillus pleuropneumoniae serovar 1. All animals in the highest dose group died within 24 hr post inoculation (hpi) and showed pulmonary lesions being hemorrhagic in nature while all animals in the lowest dose group were killed as scheduled at 11 days post inoculation (dpi) and showed only hyperplasia of peribronchial lymphoid tissues. In the middle dose group, two died within 24 hpi, two died at 9 dpi, and the remaining one was killed at 11 dpi. Two guinea pigs which died at 9 dpi showed fibrinonecrotic pleuropneumonia which is the most characteristic acute pulmonary lesion in swine, and has not yet been reproduced in laboratory animals up to the present time. This suggests that guinea pigs may be a useful laboratory animal for studying the pathogenesis of Actinobacillus pleuropneumoniae infection in swine.
format Articulo
Articulo
author Perfumo, Carlos Juan
Petruccelli, Miguel Ángel
Itagaki, Shin-ichi
author_facet Perfumo, Carlos Juan
Petruccelli, Miguel Ángel
Itagaki, Shin-ichi
author_sort Perfumo, Carlos Juan
title Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.
title_short Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.
title_full Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.
title_fullStr Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.
title_full_unstemmed Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.
title_sort pulmonary lesions in guinea pigs experimentally infected with actinobacillus pleuropneumoniae (a.p.) serovar 1.
publishDate 1999
url http://sedici.unlp.edu.ar/handle/10915/137823
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AT petruccellimiguelangel pulmonarylesionsinguineapigsexperimentallyinfectedwithactinobacilluspleuropneumoniaeapserovar1
AT itagakishinichi pulmonarylesionsinguineapigsexperimentallyinfectedwithactinobacilluspleuropneumoniaeapserovar1
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