A Reliable Biomarker Derived from Plasmalogens to Evaluate Malignancy and Metastatic Capacity of Human Cancers

Antigen tumor markers employed in monitoring therapeutical approaches are limited by their specificity (Sp) and sensitivity (Se). The aim of this study was to investigate the suitability of a lipid tumor marker derived from ether-linked phospholipids and to compare it with others usually assayed in...

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Autores principales: Smith, Rosina E., Lespi, Pablo, Di Luca, María Sandra, Bustos, Claudia, Marra, Fernando Ariel, Tacconi de Alaniz, María Josefa, Marra, Carlos Alberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Bioquímica
Ether-lipids
Breast
Lung
Prostate
Tumor markers
Human
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137745
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137745
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Ether-lipids
Breast
Lung
Prostate
Tumor markers
Human
spellingShingle Bioquímica
Ether-lipids
Breast
Lung
Prostate
Tumor markers
Human
Smith, Rosina E.
Lespi, Pablo
Di Luca, María Sandra
Bustos, Claudia
Marra, Fernando Ariel
Tacconi de Alaniz, María Josefa
Marra, Carlos Alberto
A Reliable Biomarker Derived from Plasmalogens to Evaluate Malignancy and Metastatic Capacity of Human Cancers
topic_facet Bioquímica
Ether-lipids
Breast
Lung
Prostate
Tumor markers
Human
description Antigen tumor markers employed in monitoring therapeutical approaches are limited by their specificity (Sp) and sensitivity (Se). The aim of this study was to investigate the suitability of a lipid tumor marker derived from ether-linked phospholipids and to compare it with others usually assayed in clinical practice. Complex lipids from normal and pathological breast, lung, and prostate tissue were isolated and analyzed by TLC and c-GLC methods. Results were compared as pooled samples, or by means of the averaged percent changes with respect to the composition observed in the normal tissue of the same patient. Sp, Se, negative-predictive (NPV) and positive- predictive values (PPV) were established for conventional markers and for the proposed lipid-derived marker. Results demonstrated that the content of monoenoic fatty acyl chains was significantly increased in total lipids, phosphatidylethanolamine, and especially in ethanolamine-containing ether lipids of neoplastic tissues with respect to their corresponding normal ones. Major changes were observed in the plasmalogen sub-fraction where the ratio monoenoic/saturated fatty acids can distinguish with high Se normal tissues from either benign or neoplastic tissues from breast, lung, or prostate lesions. Analyses of fatty acyl chains from ethanolamine-containing plasmalogens provided a reliable tumor marker that correlated with high Se and linearity with metastases spreading. This fact may be useful in prognosis of the most frequently observed human cancers.
format Articulo
Articulo
author Smith, Rosina E.
Lespi, Pablo
Di Luca, María Sandra
Bustos, Claudia
Marra, Fernando Ariel
Tacconi de Alaniz, María Josefa
Marra, Carlos Alberto
author_facet Smith, Rosina E.
Lespi, Pablo
Di Luca, María Sandra
Bustos, Claudia
Marra, Fernando Ariel
Tacconi de Alaniz, María Josefa
Marra, Carlos Alberto
author_sort Smith, Rosina E.
title A Reliable Biomarker Derived from Plasmalogens to Evaluate Malignancy and Metastatic Capacity of Human Cancers
title_short A Reliable Biomarker Derived from Plasmalogens to Evaluate Malignancy and Metastatic Capacity of Human Cancers
title_full A Reliable Biomarker Derived from Plasmalogens to Evaluate Malignancy and Metastatic Capacity of Human Cancers
title_fullStr A Reliable Biomarker Derived from Plasmalogens to Evaluate Malignancy and Metastatic Capacity of Human Cancers
title_full_unstemmed A Reliable Biomarker Derived from Plasmalogens to Evaluate Malignancy and Metastatic Capacity of Human Cancers
title_sort reliable biomarker derived from plasmalogens to evaluate malignancy and metastatic capacity of human cancers
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/137745
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