Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract

Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas t...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Cornejo, María Paula, De Francesco, Pablo Nicolás, García Romero, Guadalupe, Portiansky, Enrique Leo, Zigman, Jeffrey M., Reynaldo, Mirta Beatriz, Perelló, Mario Carlos
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Biología
Dorsal vagal complex
Medulla oblongata
GABA neurons
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137654
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137654
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Dorsal vagal complex
Medulla oblongata
GABA neurons
spellingShingle Biología
Dorsal vagal complex
Medulla oblongata
GABA neurons
Cornejo, María Paula
De Francesco, Pablo Nicolás
García Romero, Guadalupe
Portiansky, Enrique Leo
Zigman, Jeffrey M.
Reynaldo, Mirta Beatriz
Perelló, Mario Carlos
Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
topic_facet Biología
Dorsal vagal complex
Medulla oblongata
GABA neurons
description Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specific actions of the hormone. GHSR is highly expressed in the nucleus of the solitary tract (NTS), which is located in the medulla oblongata and controls essential functions, including orofacial, autonomic, neuroendocrine and behavioral responses. Here, we used a mouse model, in which the expression of enhanced green fluorescent protein (eGFP) is controlled by the promoter of GHSR (GHSR-eGFP mice), to gain neuroanatomical and functional insights of the GHSR-expressing neurons of the NTS. We found that GHSR-expressing neurons of the NTS are segregated in clusters that were symmetrically distributed to the midline: (1) a pair of rostral clusters, and (2) a caudal and medially located cluster. We also identified that a subset of GHSR neurons of the caudal NTS are GABAergic. Finally, we found that rostral NTS GHSR neurons increase the levels of the marker of neuronal activation c-Fos in mice exposed to fasting/refeeding or high-fat diet bingeing protocols, while caudal NTS GHSR neurons increase the levels of c-Fos in mice exposed to gastric distension or LiCl-induced malaise protocols. Thus, current data provide evidence that ghrelin receptor signaling seems to target segregated clusters of neurons within the NTS that, in turn, may be activated by different stimuli.
format Articulo
Articulo
author Cornejo, María Paula
De Francesco, Pablo Nicolás
García Romero, Guadalupe
Portiansky, Enrique Leo
Zigman, Jeffrey M.
Reynaldo, Mirta Beatriz
Perelló, Mario Carlos
author_facet Cornejo, María Paula
De Francesco, Pablo Nicolás
García Romero, Guadalupe
Portiansky, Enrique Leo
Zigman, Jeffrey M.
Reynaldo, Mirta Beatriz
Perelló, Mario Carlos
author_sort Cornejo, María Paula
title Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
title_short Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
title_full Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
title_fullStr Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
title_full_unstemmed Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
title_sort ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/137654
work_keys_str_mv AT cornejomariapaula ghrelinreceptorsignalingtargetssegregatedclustersofneuronswithinthenucleusofthesolitarytract
AT defrancescopablonicolas ghrelinreceptorsignalingtargetssegregatedclustersofneuronswithinthenucleusofthesolitarytract
AT garciaromeroguadalupe ghrelinreceptorsignalingtargetssegregatedclustersofneuronswithinthenucleusofthesolitarytract
AT portianskyenriqueleo ghrelinreceptorsignalingtargetssegregatedclustersofneuronswithinthenucleusofthesolitarytract
AT zigmanjeffreym ghrelinreceptorsignalingtargetssegregatedclustersofneuronswithinthenucleusofthesolitarytract
AT reynaldomirtabeatriz ghrelinreceptorsignalingtargetssegregatedclustersofneuronswithinthenucleusofthesolitarytract
AT perellomariocarlos ghrelinreceptorsignalingtargetssegregatedclustersofneuronswithinthenucleusofthesolitarytract
bdutipo_str Repositorios
_version_ 1764820457275523072

Ejemplares similares