Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes

The development of new vanadium derivatives with organic ligands, which improve the beneficial actions (insulin-mimetic, antitumoral) and decrease the toxic effects, is of great interest. A good candidate for the generation of a new vanadium compound is the flavonoid quercetin because of its own ant...

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Autores principales: Ferrer, Evelina Gloria, Salinas, María Victoria, Correa, María Jimena, Naso, Luciana Gissella, Barrio, Daniel Alejandro, Etcheverry, Susana Beatriz, Lezama, Luis, Rojo, Teófilo, Williams, Patricia Ana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2006
Materias:
Química
Vanadium
Quercetin
Antitumoral effects
Osteogenic effects
Osteoblasts
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137550
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137550
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Vanadium
Quercetin
Antitumoral effects
Osteogenic effects
Osteoblasts
spellingShingle Química
Vanadium
Quercetin
Antitumoral effects
Osteogenic effects
Osteoblasts
Ferrer, Evelina Gloria
Salinas, María Victoria
Correa, María Jimena
Naso, Luciana Gissella
Barrio, Daniel Alejandro
Etcheverry, Susana Beatriz
Lezama, Luis
Rojo, Teófilo
Williams, Patricia Ana María
Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes
topic_facet Química
Vanadium
Quercetin
Antitumoral effects
Osteogenic effects
Osteoblasts
description The development of new vanadium derivatives with organic ligands, which improve the beneficial actions (insulin-mimetic, antitumoral) and decrease the toxic effects, is of great interest. A good candidate for the generation of a new vanadium compound is the flavonoid quercetin because of its own anticarcinogenic effect. The complex [VO(Quer)2EtOH]; n; (QuerVO) has been synthesized and characterized by means of different spectroscopic techniques (UV–vis, Fourier transform IR, electron paramagnetic resonance) and its magnetic and stability properties. The inhibitory effect on bovine alkaline phosphatase (ALP) activity has been tested for the free ligand, the complex as well as for the vanadyl(IV) (comparative purposes). The biological activity of the complex on the proliferation of two osteoblast-like cells in culture, a normal one (MC3T3E1) and a tumoral one (UMR106), has been compared with that of the vanadyl(IV) cation and quercetin. The differentiation osteoblast markers ALP specific activity and collagen synthesis have been also tested. In addition, the effect of QuerVO on the activation of the extracellular regulated kinase (ERK) pathway is reported. The bone antitumoral effect of quercetin alone was established with the cell proliferation assays (it inhibits the proliferation of the tumoral cells and does not exert any effect on the normal osteoblasts). Moreover, the complex exerts osteogenic effects since it stimulates the type I collagen production and is a weak inhibitory agent upon ALP activity. Finally, QuerVO stimulated the ERK phosphorylation in a dose–response manner and this activation seems to be involved as one of the possible mechanisms for the biological effects of the complex.
format Articulo
Articulo
author Ferrer, Evelina Gloria
Salinas, María Victoria
Correa, María Jimena
Naso, Luciana Gissella
Barrio, Daniel Alejandro
Etcheverry, Susana Beatriz
Lezama, Luis
Rojo, Teófilo
Williams, Patricia Ana María
author_facet Ferrer, Evelina Gloria
Salinas, María Victoria
Correa, María Jimena
Naso, Luciana Gissella
Barrio, Daniel Alejandro
Etcheverry, Susana Beatriz
Lezama, Luis
Rojo, Teófilo
Williams, Patricia Ana María
author_sort Ferrer, Evelina Gloria
title Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes
title_short Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes
title_full Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes
title_fullStr Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes
title_full_unstemmed Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes
title_sort synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(iv) complexes
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/137550
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