Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina

Human cystic echinococcosis caused by the larval stage of Echinococcus granulosus sensu lato (s.l.) is a highly endemic disease in the province of Neuquen, Patagonia, Argentina. Human infections with E. granulosus sensu stricto (s.s.) G1 and Echinococcus canadensis G6 were reported in Neuquen in pre...

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Autores principales: Debiaggi, María Florencia, Soriano, Silvia Viviana, Pierangeli, Nora Beatriz, Lazzarini, Lorena Evelina, Pianciola, Luis Alfredo, Mazzeo, Melina Leonor, Moguillansky, Sergio, Basualdo Farjat, Juan Ángel
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
Echinococcus canadensis
Echinococcus granulosus
G7 genotype
Coinfection
Human echinococcosis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137246
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137246
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Echinococcus canadensis
Echinococcus granulosus
G7 genotype
Coinfection
Human echinococcosis
spellingShingle Ciencias Médicas
Echinococcus canadensis
Echinococcus granulosus
G7 genotype
Coinfection
Human echinococcosis
Debiaggi, María Florencia
Soriano, Silvia Viviana
Pierangeli, Nora Beatriz
Lazzarini, Lorena Evelina
Pianciola, Luis Alfredo
Mazzeo, Melina Leonor
Moguillansky, Sergio
Basualdo Farjat, Juan Ángel
Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina
topic_facet Ciencias Médicas
Echinococcus canadensis
Echinococcus granulosus
G7 genotype
Coinfection
Human echinococcosis
description Human cystic echinococcosis caused by the larval stage of Echinococcus granulosus sensu lato (s.l.) is a highly endemic disease in the province of Neuquen, Patagonia, Argentina. Human infections with E. granulosus sensu stricto (s.s.) G1 and Echinococcus canadensis G6 were reported in Neuquen in previous studies, whereas four genotypes were identified in livestock: G1, G3, G6, and G7. The aim of this study was to identify the genotypes of E. granulosus s.l. isolates from humans of Neuquen province, Patagonia, Argentina, through the 2005–2014 period. Twenty six hydatid cysts were obtained from 21 patients. The most frequent locations were the liver and lungs. Single cysts were observed in 81.0% of patients, and combined infection of liver and lungs was detected in 9.5% of cases. Partial sequencing of mitochondrial cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes identified the presence of E. granulosus s.s. G1 (n = 11; 42.3%) including three different partial sequences; E. canadensis G6 (n = 14; 53.8%) and E. canadensis G7 (n = 1; 3.9%). Coinfection with G1 and G7 genotypes was detected in one patient who harbored three liver cysts. Most of the liver cysts corresponded to G1 and G6 genotypes. This study presents the first report in the Americas of a human infection with E. canadensis G7 and the second worldwide report of a coinfection with two different species and genotypes of E. granulosus s.l in humans. The molecular diversity of this parasite should be considered to redesign or improve the control program strategies in endemic regions.
format Articulo
Comunicacion
author Debiaggi, María Florencia
Soriano, Silvia Viviana
Pierangeli, Nora Beatriz
Lazzarini, Lorena Evelina
Pianciola, Luis Alfredo
Mazzeo, Melina Leonor
Moguillansky, Sergio
Basualdo Farjat, Juan Ángel
author_facet Debiaggi, María Florencia
Soriano, Silvia Viviana
Pierangeli, Nora Beatriz
Lazzarini, Lorena Evelina
Pianciola, Luis Alfredo
Mazzeo, Melina Leonor
Moguillansky, Sergio
Basualdo Farjat, Juan Ángel
author_sort Debiaggi, María Florencia
title Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina
title_short Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina
title_full Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina
title_fullStr Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina
title_full_unstemmed Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina
title_sort genetic characterization of human hydatid cysts shows coinfection by echinococcus canadensis g7 and echinococcus granulosus sensu stricto g1 in argentina
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/137246
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