Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization

Non-specific enhancement of the airways innate response has been shown to impair lung infections in several models of infection such diverse as influenza A, Streptococcus pneumoniae, and Aspergillus niger. Our aim was to evaluate whether a similar event could operate in the context of Bordetella per...

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Detalles Bibliográficos
Autores principales: Errea, Agustina Juliana, Moreno, Griselda Noemí, Sisti, Federico, Fernández, Julieta, Rumbo, Martín, Hozbor, Daniela Flavia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Biología
Bordetella pertussis
Stimulated innate resistance
TLR4
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137236
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137236
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Bordetella pertussis
Stimulated innate resistance
TLR4
spellingShingle Biología
Bordetella pertussis
Stimulated innate resistance
TLR4
Errea, Agustina Juliana
Moreno, Griselda Noemí
Sisti, Federico
Fernández, Julieta
Rumbo, Martín
Hozbor, Daniela Flavia
Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization
topic_facet Biología
Bordetella pertussis
Stimulated innate resistance
TLR4
description Non-specific enhancement of the airways innate response has been shown to impair lung infections in several models of infection such diverse as influenza A, Streptococcus pneumoniae, and Aspergillus niger. Our aim was to evaluate whether a similar event could operate in the context of Bordetella pertussis respiratory infection, not only to enrich the knowledge of host-bacteria interaction but also to establish immunological basis for the development of new control strategies against the pathogen. Using a B. pertussis intranasal infection model and coadministration of different TLR agonists at the moment of the infection, we observed that the enhancement of innate response activation, in a TLR4-dependent way, could efficiently impair B. pertussis colonization (P < 0.001). While LPS from different microbial sources were equally effective in promoting this effect, flagellin and poly I:C coadministration, in spite of inducing expression of innate response markers TNFalpha, CXCL2, CXCL10 and IL6, was not effective to prevent B. pertussis colonization. Our results indicate that during the early stage of infection, specific anti-microbial mechanisms triggered by TLR4 stimulation are able to impair B. pertussis colonization. These findings could complement our current view of the role of TLR4-dependent processes that contribute to anti-pertussis immunity.
format Articulo
Articulo
author Errea, Agustina Juliana
Moreno, Griselda Noemí
Sisti, Federico
Fernández, Julieta
Rumbo, Martín
Hozbor, Daniela Flavia
author_facet Errea, Agustina Juliana
Moreno, Griselda Noemí
Sisti, Federico
Fernández, Julieta
Rumbo, Martín
Hozbor, Daniela Flavia
author_sort Errea, Agustina Juliana
title Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization
title_short Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization
title_full Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization
title_fullStr Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization
title_full_unstemmed Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization
title_sort mucosal innate response stimulation induced by lipopolysaccharide protects against bordetella pertussis colonization
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/137236
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