Effect of ethanol administration on fatty acid desaturation

The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The Δ6 and Δ5 desatur...

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Autores principales: Nervi, Aníbal M., Peluffo, Raúl Omar, Brenner, Rodolfo Roberto, Leikin, Alicia Isabel
Formato: Articulo
Lenguaje:Inglés
Publicado: 1980
Materias:
Bioquímica
Ethanol
Fatty acid
Lipidic
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/136621
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-136621
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Ethanol
Fatty acid
Lipidic
spellingShingle Bioquímica
Ethanol
Fatty acid
Lipidic
Nervi, Aníbal M.
Peluffo, Raúl Omar
Brenner, Rodolfo Roberto
Leikin, Alicia Isabel
Effect of ethanol administration on fatty acid desaturation
topic_facet Bioquímica
Ethanol
Fatty acid
Lipidic
description The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The Δ6 and Δ5 desaturases were inhibited by ethanol whereas the Δ9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of Δ6 and Δ5 desaturases by ethanol.
format Articulo
Articulo
author Nervi, Aníbal M.
Peluffo, Raúl Omar
Brenner, Rodolfo Roberto
Leikin, Alicia Isabel
author_facet Nervi, Aníbal M.
Peluffo, Raúl Omar
Brenner, Rodolfo Roberto
Leikin, Alicia Isabel
author_sort Nervi, Aníbal M.
title Effect of ethanol administration on fatty acid desaturation
title_short Effect of ethanol administration on fatty acid desaturation
title_full Effect of ethanol administration on fatty acid desaturation
title_fullStr Effect of ethanol administration on fatty acid desaturation
title_full_unstemmed Effect of ethanol administration on fatty acid desaturation
title_sort effect of ethanol administration on fatty acid desaturation
publishDate 1980
url http://sedici.unlp.edu.ar/handle/10915/136621
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AT brennerrodolforoberto effectofethanoladministrationonfattyaciddesaturation
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