Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats

This paper addresses the effect of a reduction of uterine blood flow (RUB) on postcranial bone growth in rats. The objectives were: (1) to discover and characterize the changes evoked by growth retardation through a reduction in placental blood flow, (2) to see if the resulting growth retardation is...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Oyhenart, Evelia Edith, Cesani Rossi, María Florencia, Castro, Luis Eduardo, Quintero, Fabián Aníbal, Fucini, María Cecilia, Luna, María Eugenia, Guimarey, Luis Manuel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Veterinaria
Intrauterine growth retardation
Sexual dimorphism
Bone growth
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/136531
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-136531
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Veterinaria
Intrauterine growth retardation
Sexual dimorphism
Bone growth
spellingShingle Veterinaria
Intrauterine growth retardation
Sexual dimorphism
Bone growth
Oyhenart, Evelia Edith
Cesani Rossi, María Florencia
Castro, Luis Eduardo
Quintero, Fabián Aníbal
Fucini, María Cecilia
Luna, María Eugenia
Guimarey, Luis Manuel
Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
topic_facet Veterinaria
Intrauterine growth retardation
Sexual dimorphism
Bone growth
description This paper addresses the effect of a reduction of uterine blood flow (RUB) on postcranial bone growth in rats. The objectives were: (1) to discover and characterize the changes evoked by growth retardation through a reduction in placental blood flow, (2) to see if the resulting growth retardation is different in each bone, and (3) to analyze any sex-specific features. RUB was induced by the partial bending of uterine vessels at day 1 of pregnancy. Control and sham-operated animals were also included. The animals were X-rayed at birth. The lengths and widths of the humerus, radius, and femur and pelvic length, interischial, interpubic, and pubic widths were measured. Data were analyzed by ANOVA and LSD post hoc tests. The intersubject analysis showed significant differences between groups and non-significant differences between sexes. In males, sham-operated and RUB showed significant differences in pelvic lengths and widths, and humeral, radial, femoral, and tibial widths. In females, there were significant differences only for humeral widths, radial lengths and widths, and femoral and tibial widths. We conclude that reduced blood flow delays appendicular bone growth as observed at birth. Pelvic length was more affected than that of the limbs. The widths of the pelvic and limbs bones, in turn, were more altered than the lengths, and the growth of the males more than that of the females. Partial bending of uterine vessels compromised postcranial growth, though under such disadvantageous circumstances the females proved to be more capable of growing and thus more resilient than the males.
format Articulo
Articulo
author Oyhenart, Evelia Edith
Cesani Rossi, María Florencia
Castro, Luis Eduardo
Quintero, Fabián Aníbal
Fucini, María Cecilia
Luna, María Eugenia
Guimarey, Luis Manuel
author_facet Oyhenart, Evelia Edith
Cesani Rossi, María Florencia
Castro, Luis Eduardo
Quintero, Fabián Aníbal
Fucini, María Cecilia
Luna, María Eugenia
Guimarey, Luis Manuel
author_sort Oyhenart, Evelia Edith
title Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
title_short Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
title_full Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
title_fullStr Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
title_full_unstemmed Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
title_sort bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/136531
work_keys_str_mv AT oyhenarteveliaedith bonegrowthandsexualdimorphismatbirthinintrauterinegrowthretardedrats
AT cesanirossimariaflorencia bonegrowthandsexualdimorphismatbirthinintrauterinegrowthretardedrats
AT castroluiseduardo bonegrowthandsexualdimorphismatbirthinintrauterinegrowthretardedrats
AT quinterofabiananibal bonegrowthandsexualdimorphismatbirthinintrauterinegrowthretardedrats
AT fucinimariacecilia bonegrowthandsexualdimorphismatbirthinintrauterinegrowthretardedrats
AT lunamariaeugenia bonegrowthandsexualdimorphismatbirthinintrauterinegrowthretardedrats
AT guimareyluismanuel bonegrowthandsexualdimorphismatbirthinintrauterinegrowthretardedrats
bdutipo_str Repositorios
_version_ 1764820456987164672

Ejemplares similares