First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure

Porcine circovirus type 3 (PCV3) is considered a new circovirus and since it first description has been widely reported in most of the swine-producing countries. Multisystemic inflammation and reproductive failure are consistent and concerning issues associated with PCV3 infection. This report descr...

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Detalles Bibliográficos
Autores principales: Serena, María Soledad, Cappuccio, Javier Alejandro, Barrales, Hernán, Metz, Germán Ernesto, Aspitia, Carolina Gabriela, Lozada, María Inés, Perfumo, Carlos Juan, Quiroga, María Alejandra, Piñeyro Piñeiro, Pablo Enrique, Echeverría, María Gabriela
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Veterinarias
Porcine Circovirus 3
reproductive failure
genetic characterization
Argentina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/136008
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-136008
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Porcine Circovirus 3
reproductive failure
genetic characterization
Argentina
spellingShingle Ciencias Veterinarias
Porcine Circovirus 3
reproductive failure
genetic characterization
Argentina
Serena, María Soledad
Cappuccio, Javier Alejandro
Barrales, Hernán
Metz, Germán Ernesto
Aspitia, Carolina Gabriela
Lozada, María Inés
Perfumo, Carlos Juan
Quiroga, María Alejandra
Piñeyro Piñeiro, Pablo Enrique
Echeverría, María Gabriela
First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
topic_facet Ciencias Veterinarias
Porcine Circovirus 3
reproductive failure
genetic characterization
Argentina
description Porcine circovirus type 3 (PCV3) is considered a new circovirus and since it first description has been widely reported in most of the swine-producing countries. Multisystemic inflammation and reproductive failure are consistent and concerning issues associated with PCV3 infection. This report describes the clinical and pathological features of a chronic reproductive disorder in a swine herd in Argentina associated with the presence of PCV3. Mummified (n = 42) and stillborn piglets (n = 20) from a case of chronic reproductive disorder (Study A) and mummified and stillborn piglets (n = 141) from normal deliveries (Study B) were retrospectively assessed for the presence of multiple reproductive pathogens (PCV3, PCV2, ADV, PPV, Leptospira spp. and Brucella spp). On study, A PCV3 and PPV were detected in 15 and 8 pools, respectively, with a coinfection rate of 100% in all PPV-positive cases. Three out of 131 foetuses from three different sows from Study B were positive only for PCV3. Histological evaluation of hearts from stillborn also showed lesions similar to those previously described in the literature for PCV3-reproductive disease. Partial genome of PCV3 was amplified and phylogenetic analysis showed that strains of Study A and B clustered within the PCV3a and PCV3b clades, respectively. This study demonstrates, for the first time, the PCV3 has been circulating in Argentina at least since 2016 and its potential role in reproductive disorders. Further studies are warranted to determine the role of PCV3 in the reproductive disease complex and its prevalence in the swine industry in Argentina.
format Articulo
Preprint
author Serena, María Soledad
Cappuccio, Javier Alejandro
Barrales, Hernán
Metz, Germán Ernesto
Aspitia, Carolina Gabriela
Lozada, María Inés
Perfumo, Carlos Juan
Quiroga, María Alejandra
Piñeyro Piñeiro, Pablo Enrique
Echeverría, María Gabriela
author_facet Serena, María Soledad
Cappuccio, Javier Alejandro
Barrales, Hernán
Metz, Germán Ernesto
Aspitia, Carolina Gabriela
Lozada, María Inés
Perfumo, Carlos Juan
Quiroga, María Alejandra
Piñeyro Piñeiro, Pablo Enrique
Echeverría, María Gabriela
author_sort Serena, María Soledad
title First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_short First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_full First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_fullStr First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_full_unstemmed First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_sort first detection and genetic characterization of porcine circovirus type 3 (pcv3) in argentina and its association with reproductive failure
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/136008
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