Surveillance of SARS-CoV-2 variants in Argentina: detection of Alpha, Gamma, Lambda, Epsilon and Zeta in locally transmitted and imported cases

Molecular surveillance of SARS-CoV-2 variants was performed on a total of 2,406 samples from the capital city and nine provinces of Argentina, during 30 epidemiological weeks (EW) that covered the end of the first wave and the beginning of the ongoing second wave of the COVID-19 pandemic in the coun...

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Detalles Bibliográficos
Autores principales: Angelletti, Andrés, Cordero, Andrés Ignacio, Toro, Rosana
Formato: Articulo Preprint
Lenguaje:Español
Publicado: 2021
Materias:
Ciencias Médicas
SARS-CoV-2
variants
South America
Argentina
Surveillance
Spike sequence
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/136006
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-136006
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Médicas
SARS-CoV-2
variants
South America
Argentina
Surveillance
Spike sequence
spellingShingle Ciencias Médicas
SARS-CoV-2
variants
South America
Argentina
Surveillance
Spike sequence
Angelletti, Andrés
Cordero, Andrés Ignacio
Toro, Rosana
Surveillance of SARS-CoV-2 variants in Argentina: detection of Alpha, Gamma, Lambda, Epsilon and Zeta in locally transmitted and imported cases
topic_facet Ciencias Médicas
SARS-CoV-2
variants
South America
Argentina
Surveillance
Spike sequence
description Molecular surveillance of SARS-CoV-2 variants was performed on a total of 2,406 samples from the capital city and nine provinces of Argentina, during 30 epidemiological weeks (EW) that covered the end of the first wave and the beginning of the ongoing second wave of the COVID-19 pandemic in the country (EW 44/2020 to EW 20/2021). The surveillance strategy was mainly based on Sanger sequencing of a Spike coding region that allows the simultaneous identification of signature mutations associated with worldwide circulating variants. In addition, whole SARS-CoV-2 genome sequences were obtained from 456 samples. The main variants found were Gamma, Lambda and Alpha, and to a lesser extent, Zeta and Epsilon. Whereas Gamma dominated in different regions of the country, both Gamma and Lambda prevailed in the most populated area, the metropolitan region of Buenos Aires (MABA), although showing a heterogeneous distribution along this region. This cost-effective surveillance protocol allowed for a rapid response in a limited access to resources scenario, added information on the expansion of the Lambda variant in South America and contributed to the implementation of public health measures to control the disease spread in Argentina.
format Articulo
Preprint
author Angelletti, Andrés
Cordero, Andrés Ignacio
Toro, Rosana
author_facet Angelletti, Andrés
Cordero, Andrés Ignacio
Toro, Rosana
author_sort Angelletti, Andrés
title Surveillance of SARS-CoV-2 variants in Argentina: detection of Alpha, Gamma, Lambda, Epsilon and Zeta in locally transmitted and imported cases
title_short Surveillance of SARS-CoV-2 variants in Argentina: detection of Alpha, Gamma, Lambda, Epsilon and Zeta in locally transmitted and imported cases
title_full Surveillance of SARS-CoV-2 variants in Argentina: detection of Alpha, Gamma, Lambda, Epsilon and Zeta in locally transmitted and imported cases
title_fullStr Surveillance of SARS-CoV-2 variants in Argentina: detection of Alpha, Gamma, Lambda, Epsilon and Zeta in locally transmitted and imported cases
title_full_unstemmed Surveillance of SARS-CoV-2 variants in Argentina: detection of Alpha, Gamma, Lambda, Epsilon and Zeta in locally transmitted and imported cases
title_sort surveillance of sars-cov-2 variants in argentina: detection of alpha, gamma, lambda, epsilon and zeta in locally transmitted and imported cases
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/136006
work_keys_str_mv AT angellettiandres surveillanceofsarscov2variantsinargentinadetectionofalphagammalambdaepsilonandzetainlocallytransmittedandimportedcases
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