Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids

Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulatio...

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Detalles Bibliográficos
Autores principales: Costas, Luciana, Pera, Licia María, Gómez López, Azucena, Mechetti, Magdalena, Castro, Guillermo Raúl
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/135819
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-135819
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
spellingShingle Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
Costas, Luciana
Pera, Licia María
Gómez López, Azucena
Mechetti, Magdalena
Castro, Guillermo Raúl
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
topic_facet Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
description Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively.
format Articulo
Articulo
author Costas, Luciana
Pera, Licia María
Gómez López, Azucena
Mechetti, Magdalena
Castro, Guillermo Raúl
author_facet Costas, Luciana
Pera, Licia María
Gómez López, Azucena
Mechetti, Magdalena
Castro, Guillermo Raúl
author_sort Costas, Luciana
title Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_short Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_full Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_fullStr Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_full_unstemmed Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_sort controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/135819
work_keys_str_mv AT costasluciana controlledreleaseofsulfasalazinereleasefromsmartpectingelmicrospheresunderphysiologicalsimulatedfluids
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AT mechettimagdalena controlledreleaseofsulfasalazinereleasefromsmartpectingelmicrospheresunderphysiologicalsimulatedfluids
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bdutipo_str Repositorios
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