Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes

The present study is devoted to the synthesis of 4-chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and its transition metal complexes. Synthesis of the ligand has been achieved by the condensation reaction of N,N-diethylsalicylaldehyde with 4-chloro-2-aminophenol in acidic medium. Meta...

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Detalles Bibliográficos
Autores principales:	Abbas, Naeem, Shabir, Ghulam, Saeed, Aamer, Tirmizi, Syed Ahmad, Echeverría, Gustavo Alberto, Piro, Oscar Enrique, Erben, Mauricio Federico
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2020
Materias:	Física Química anticancer activity HeLa cell line azomethine condensation reaction spectroscopic methods
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/135414
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-135414
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Física Química anticancer activity HeLa cell line azomethine condensation reaction spectroscopic methods
spellingShingle	Física Química anticancer activity HeLa cell line azomethine condensation reaction spectroscopic methods Abbas, Naeem Shabir, Ghulam Saeed, Aamer Tirmizi, Syed Ahmad Echeverría, Gustavo Alberto Piro, Oscar Enrique Erben, Mauricio Federico Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes
topic_facet	Física Química anticancer activity HeLa cell line azomethine condensation reaction spectroscopic methods
description	The present study is devoted to the synthesis of 4-chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and its transition metal complexes. Synthesis of the ligand has been achieved by the condensation reaction of N,N-diethylsalicylaldehyde with 4-chloro-2-aminophenol in acidic medium. Metals complexes of the ligand with different transition metal ions [M²⁺= Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), and Pd(II)] have been accumulated in alcoholic media and characterized by spectroscopic methods. UV-Vis analysis of the complexes indicates the ligand coordination to the metal ions via both OH groups and the azomethine nitrogen atom, acting as a tridentate ligand. Anticancer tests of selected complexes demonstrate moderate in vitro activity of Cu(II) complex against HeLa cell line.
format	Articulo Articulo
author	Abbas, Naeem Shabir, Ghulam Saeed, Aamer Tirmizi, Syed Ahmad Echeverría, Gustavo Alberto Piro, Oscar Enrique Erben, Mauricio Federico
author_facet	Abbas, Naeem Shabir, Ghulam Saeed, Aamer Tirmizi, Syed Ahmad Echeverría, Gustavo Alberto Piro, Oscar Enrique Erben, Mauricio Federico
author_sort	Abbas, Naeem
title	Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes
title_short	Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes
title_full	Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes
title_fullStr	Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes
title_full_unstemmed	Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes
title_sort	synthesis and structure of 4-chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and its metal complexes
publishDate	2020
url	http://sedici.unlp.edu.ar/handle/10915/135414
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bdutipo_str	Repositorios
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Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes

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