Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome

(1) Evaluate mortality rate in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome, (2) determine the leading causes of death, and (3) identify predictors of mortality at hospital admission. We conducted a multicentric, observational, retrospective, cross-sectional study....

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Autores principales: Alconcher, Laura F., Coccia, Paula A., Suarez, Angela del Carmen, Monteverde, Marta L., Pérez Y Gutiérrez, María Graciela, Carlopio, Paula M., Missoni, Mabel, Balestracci, Alejandro, Principi, Illiana, Ramírez, Flavia B., Estrella, Patricia, Micelli, Susana, Leroy, Daniela C., Quijada, Nahir E., Seminara, Claudia, Giordano, Marta I., Hidalgo Solís, Susana B., Saurit, Mariana, Caminitti, Alejandra, Arias, Andrea, Rivas, Marta, Risso, Paula, Liern, Miguel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Médicas
Thrombotic microangiopathy
Acute kidney injury
Outcome in typical uremic syndrome
Typical hemolytic uremic syndrome
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/134991
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-134991
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Thrombotic microangiopathy
Acute kidney injury
Outcome in typical uremic syndrome
Typical hemolytic uremic syndrome
spellingShingle Ciencias Médicas
Thrombotic microangiopathy
Acute kidney injury
Outcome in typical uremic syndrome
Typical hemolytic uremic syndrome
Alconcher, Laura F.
Coccia, Paula A.
Suarez, Angela del Carmen
Monteverde, Marta L.
Pérez Y Gutiérrez, María Graciela
Carlopio, Paula M.
Missoni, Mabel
Balestracci, Alejandro
Principi, Illiana
Ramírez, Flavia B.
Estrella, Patricia
Micelli, Susana
Leroy, Daniela C.
Quijada, Nahir E.
Seminara, Claudia
Giordano, Marta I.
Hidalgo Solís, Susana B.
Saurit, Mariana
Caminitti, Alejandra
Arias, Andrea
Rivas, Marta
Risso, Paula
Liern, Miguel
Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome
topic_facet Ciencias Médicas
Thrombotic microangiopathy
Acute kidney injury
Outcome in typical uremic syndrome
Typical hemolytic uremic syndrome
description (1) Evaluate mortality rate in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome, (2) determine the leading causes of death, and (3) identify predictors of mortality at hospital admission. We conducted a multicentric, observational, retrospective, cross-sectional study. It included patients under 18 years old with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome hospitalized between January 2005 and June 2016. Clinical and laboratory data were obtained from the Argentine National Epidemiological Surveillance System of Hemolytic Uremic Syndrome. Clinical and laboratory variables were compared between deceased and non-deceased patients. Univariate and multivariate analyses were performed. ROC curves and area under the curve were obtained. Seventeen (3.65%) out of the 466 patients died, being central nervous system involvement the main cause of death. Predictors of death were central nervous system involvement, the number of days since the beginning of diarrhea to hospitalization, hyponatremia, high hemoglobin, high leukocyte counts, and low bicarbonate concentration on admission. In the multivariate analysis, central nervous system involvement, sodium concentration, and hemoglobin were independent predictors. The best cut off for sodium was ≤ 128 meq/l and for hemoglobin ≥ 10.8 g/dl. Mortality was low in children with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome, being central nervous system involvement the main cause of death. The best mortality predictors found were central nervous system involvement, hemoglobin, and sodium concentration. Hyponatremia may be a new Shiga toxin-producing Escherichia coli hemolytic uremic syndrome mortality predictor.
format Articulo
Articulo
author Alconcher, Laura F.
Coccia, Paula A.
Suarez, Angela del Carmen
Monteverde, Marta L.
Pérez Y Gutiérrez, María Graciela
Carlopio, Paula M.
Missoni, Mabel
Balestracci, Alejandro
Principi, Illiana
Ramírez, Flavia B.
Estrella, Patricia
Micelli, Susana
Leroy, Daniela C.
Quijada, Nahir E.
Seminara, Claudia
Giordano, Marta I.
Hidalgo Solís, Susana B.
Saurit, Mariana
Caminitti, Alejandra
Arias, Andrea
Rivas, Marta
Risso, Paula
Liern, Miguel
author_facet Alconcher, Laura F.
Coccia, Paula A.
Suarez, Angela del Carmen
Monteverde, Marta L.
Pérez Y Gutiérrez, María Graciela
Carlopio, Paula M.
Missoni, Mabel
Balestracci, Alejandro
Principi, Illiana
Ramírez, Flavia B.
Estrella, Patricia
Micelli, Susana
Leroy, Daniela C.
Quijada, Nahir E.
Seminara, Claudia
Giordano, Marta I.
Hidalgo Solís, Susana B.
Saurit, Mariana
Caminitti, Alejandra
Arias, Andrea
Rivas, Marta
Risso, Paula
Liern, Miguel
author_sort Alconcher, Laura F.
title Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome
title_short Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome
title_full Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome
title_fullStr Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome
title_full_unstemmed Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome
title_sort hyponatremia: a new predictor of mortality in patients with shiga toxin-producing escherichia coli hemolytic uremic syndrome
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/134991
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