Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina

Background Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient...

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Autores principales: Fallo, A., Neyro, Silvina E., Manonelles, Gabriela, Lara, Claudia, Hozbor, Daniela Flavia, Zintgraff, Jonathan, Mazzeo, Silvina, Davison, Héctor E., González, Susana, Zapulla, Estella, Canle, Oscar, Huespe, Miguel, Galas, Marcelo, Lopez, E. L.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/134850
Aporte de:
id I19-R120-10915-134850
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
maternal immunization
pertussis
placental transfer of antibodies
pregnancy vaccines
Tdap immunization
spellingShingle Biología
maternal immunization
pertussis
placental transfer of antibodies
pregnancy vaccines
Tdap immunization
Fallo, A.
Neyro, Silvina E.
Manonelles, Gabriela
Lara, Claudia
Hozbor, Daniela Flavia
Zintgraff, Jonathan
Mazzeo, Silvina
Davison, Héctor E.
González, Susana
Zapulla, Estella
Canle, Oscar
Huespe, Miguel
Galas, Marcelo
Lopez, E. L.
Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina
topic_facet Biología
maternal immunization
pertussis
placental transfer of antibodies
pregnancy vaccines
Tdap immunization
description Background Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient to protect young infants. To our knowledge, no previous reports of maternal pertussis immunization results in Latin America exist in the literature. Methods This study compared pertussis antibody levels in newborns from mothers who received or did not receive a tetanus-diphtheria-acellular pertussis vaccination (TdapV) during pregnancy. Each mother's level of immunoglobulin G antibodies against pertussis toxin (IgG-PT) was measured with a validated, specific enzyme-linked immunosorbent assay (ELISA). Results Paired mother and cord serum samples were compared in 105 mothers with and 99 mothers without a TdapV. At birth, the mothers with and those without a TdapV had serum IgG-PT geometric mean concentrations (GMCs) of 35.1 and 9.8 ELISA units (EU)/mL, respectively (P < .0001); cord blood GMCs were 51.3 and 11.6 EU/mL, respectively (P < .0003); and cord blood IgG-PT levels were <5 EU/mL in 2.9% and 16.1% of the cord blood samples, respectively (P < .001). The mothers received their TdapV at a mean (± standard deviation [SD]) of 24.7 ± 4.8 weeks' gestation. Vaccination timing did not affect the IgG-PT GMC at birth. Placental antibody transference efficiencies (measured as the ratio of the cord blood GMC to the maternal GMC) were 1.46 and 1.18 for mothers with and those without a TdapV, respectively. The IgG-PT GMCs were 17.7 EU/mL in 36 infants in their first month of life and 11.6 EU/mL in 32 infants in their second month of life. Conclusions Women who received a TdapV during pregnancy had significantly a higher serum/cord IgG-PT concentration at birth than mothers who did not receive a TdapV. Timing of the immunization was not correlated with antibody concentrations. Infants born to immunized mothers had significantly higher antibody levels during their first 2 months of life.
format Articulo
Articulo
author Fallo, A.
Neyro, Silvina E.
Manonelles, Gabriela
Lara, Claudia
Hozbor, Daniela Flavia
Zintgraff, Jonathan
Mazzeo, Silvina
Davison, Héctor E.
González, Susana
Zapulla, Estella
Canle, Oscar
Huespe, Miguel
Galas, Marcelo
Lopez, E. L.
author_facet Fallo, A.
Neyro, Silvina E.
Manonelles, Gabriela
Lara, Claudia
Hozbor, Daniela Flavia
Zintgraff, Jonathan
Mazzeo, Silvina
Davison, Héctor E.
González, Susana
Zapulla, Estella
Canle, Oscar
Huespe, Miguel
Galas, Marcelo
Lopez, E. L.
author_sort Fallo, A.
title Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina
title_short Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina
title_full Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina
title_fullStr Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina
title_full_unstemmed Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina
title_sort prevalence of pertussis antibodies in maternal blood, cord serum, and infants from mothers with and those without tdap booster vaccination during pregnancy in argentina
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/134850
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