Mesoscopic oscillations in a single-gene circuit without delay
It is well known that single-gene circuits with negative feedback loop can lead to oscillatory gene expression when they operate with time delay. In order to generate these oscillations many processes can contribute to properly timing such delay. Here we show that the time delay coming from the tran...
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Autores principales: | , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
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2016
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/134782 |
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I19-R120-10915-134782 |
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institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Ciencias Exactas Física single-gene circuits oscillatory gene expression cis-regulatory system |
spellingShingle |
Ciencias Exactas Física single-gene circuits oscillatory gene expression cis-regulatory system Guisoni, Nara Cristina Monteoliva, Diana Diambra, Luis Aníbal Mesoscopic oscillations in a single-gene circuit without delay |
topic_facet |
Ciencias Exactas Física single-gene circuits oscillatory gene expression cis-regulatory system |
description |
It is well known that single-gene circuits with negative feedback loop can lead to oscillatory gene expression when they operate with time delay. In order to generate these oscillations many processes can contribute to properly timing such delay. Here we show that the time delay coming from the transitions between internal states of the cis-regulatory system (CRS) can drive sustained oscillations in an auto-repressive single-gene circuit operating in a small volume like a cell. We found that the cooperative binding of repressor molecules is not mandatory for a oscillatory behavior if there are enough binding sites in the CRS. These oscillations depend on an adequate balance between the CRS kinetic, and the synthesis/degradation rates of repressor molecules. This finding suggest that the multi-site CRS architecture plays a key role for oscillatory behavior of gene expression. |
format |
Articulo Articulo |
author |
Guisoni, Nara Cristina Monteoliva, Diana Diambra, Luis Aníbal |
author_facet |
Guisoni, Nara Cristina Monteoliva, Diana Diambra, Luis Aníbal |
author_sort |
Guisoni, Nara Cristina |
title |
Mesoscopic oscillations in a single-gene circuit without delay |
title_short |
Mesoscopic oscillations in a single-gene circuit without delay |
title_full |
Mesoscopic oscillations in a single-gene circuit without delay |
title_fullStr |
Mesoscopic oscillations in a single-gene circuit without delay |
title_full_unstemmed |
Mesoscopic oscillations in a single-gene circuit without delay |
title_sort |
mesoscopic oscillations in a single-gene circuit without delay |
publishDate |
2016 |
url |
http://sedici.unlp.edu.ar/handle/10915/134782 |
work_keys_str_mv |
AT guisoninaracristina mesoscopicoscillationsinasinglegenecircuitwithoutdelay AT monteolivadiana mesoscopicoscillationsinasinglegenecircuitwithoutdelay AT diambraluisanibal mesoscopicoscillationsinasinglegenecircuitwithoutdelay |
bdutipo_str |
Repositorios |
_version_ |
1764820455457292289 |