Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production

This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the...

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Detalles Bibliográficos
Autores principales: Monsalve-Bravo, Gloria M, Garelli, Fabricio, Mozumder, Salatul Islam, Alvarez, Hernan, De Battista, Hernán
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ingeniería
Scale-up
Bioprocess
Hankel matrix
Dynamics hierarchy
Output impactability index
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/134699
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-134699
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ingeniería
Scale-up
Bioprocess
Hankel matrix
Dynamics hierarchy
Output impactability index
spellingShingle Ingeniería
Scale-up
Bioprocess
Hankel matrix
Dynamics hierarchy
Output impactability index
Monsalve-Bravo, Gloria M
Garelli, Fabricio
Mozumder, Salatul Islam
Alvarez, Hernan
De Battista, Hernán
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
topic_facet Ingeniería
Scale-up
Bioprocess
Hankel matrix
Dynamics hierarchy
Output impactability index
description This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.
format Articulo
Articulo
author Monsalve-Bravo, Gloria M
Garelli, Fabricio
Mozumder, Salatul Islam
Alvarez, Hernan
De Battista, Hernán
author_facet Monsalve-Bravo, Gloria M
Garelli, Fabricio
Mozumder, Salatul Islam
Alvarez, Hernan
De Battista, Hernán
author_sort Monsalve-Bravo, Gloria M
title Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_short Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_full Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_fullStr Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_full_unstemmed Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
title_sort model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (phb) production
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/134699
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